Journal article
dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction
Journal of virology, Vol.99(5), e00302-25
05/20/2025
DOI: 10.1128/jvi.00302-25
PMCID: PMC12090746
PMID: 40277359
Abstract
SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its dNTPase activity. Instead, the versatility of SAMHD1-mediated restriction of various viruses suggests that its antiviral mechanisms extend beyond dNTP depletion. This explains the multifaceted and broad restriction functions of SAMHD1 that play a significant role in innate antiviral immunity.
Details
- Title: Subtitle
- dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction
- Creators
- Pak-Hin Hinson Cheung - University of IowaHua Yang - University of IowaLi Wu - University of Iowa
- Contributors
- David E. Levy (Editor)
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.99(5), e00302-25
- DOI
- 10.1128/jvi.00302-25
- PMID
- 40277359
- PMCID
- PMC12090746
- NLM abbreviation
- J Virol
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Publisher
- American Society for Microbiology
- Number of pages
- 13
- Grant note
- R01AI141495, R61AI169659, R21AI181742, R21AI170070, P30CA086862-24S1 / National Institutes of Health (http://dx.doi.org/10.13039/100000002)
- Language
- English
- Electronic publication date
- 04/25/2025
- Date published
- 05/20/2025
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984813291602771
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