Journal article
fMRI detection of early neural dysfunction in preclinical Huntington's disease
Journal of the International Neuropsychological Society, Vol.13(5), pp.758-769
09/2007
DOI: 10.1017/S1355617707071214
PMID: 17697407
Abstract
Neuropsychological and neuroimaging changes have been observed in individuals with the Huntington's disease (HD) gene expansion prior to the onset of manifest HD. This cross-sectional fMRI study of preclinical HD (pre-HD) individuals was conducted to determine if functional brain changes precede deficits in behavioral performance and striatal atrophy. Twenty-six pre-HD and 13 demographically matched healthy participants performed a time reproduction task while undergoing fMRI scanning. Pre-HD participants were divided into two groups (n=13 each): FAR (>12 years to estimated onset [YEO] of manifest HD) and CLOSE (<12 YEO). The CLOSE group demonstrated behavioral deficits, striatal atrophy, and reduced neural activation in the left putamen, SMA, left anterior insula and right inferior frontal gyrus. The FAR group showed reduced neural activation in the right anterior cingulate and right anterior insula. The FAR group also demonstrated increased neural activation in the left sensorimotor, left medial frontal gyrus, left precentral gyrus, bilateral superior temporal gyri and right cerebellum. The fMRI changes in the FAR group occurred in the relative absence of striatal atrophy and behavioral performance deficits. These results suggest that fMRI is sensitive to neural dysfunction occurring more than 12 years prior to the estimated onset of manifest HD.
Details
- Title: Subtitle
- fMRI detection of early neural dysfunction in preclinical Huntington's disease
- Creators
- Janice L Zimbelman - Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, and Schey Center for Cognitive Neuroimaging, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USAJane S PaulsenAnia MikosNorman C ReynoldsRaymond G HoffmannStephen M Rao
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.13(5), pp.758-769
- DOI
- 10.1017/S1355617707071214
- PMID
- 17697407
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Grant note
- R01 NS054893 / NINDS NIH HHS M01 RR00058 / NCRR NIH HHS
- Language
- English
- Date published
- 09/2007
- Academic Unit
- Psychiatry; Psychological and Brain Sciences
- Record Identifier
- 9984083841802771
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