fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder

Caleb M Adler; Patricia McDonough-Ryan; Kenji W Sax; Scott K Holland; Stephan Arndt; Stephen M Strakowski

doi:10.1016/S0022-3956(00)00022-4

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fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder

Journal article

Peer reviewed

fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder

Caleb M Adler, Patricia McDonough-Ryan, Kenji W Sax, Scott K Holland, Stephan Arndt and Stephen M Strakowski

Journal of psychiatric research, Vol.34(4), pp.317-324

07/01/2000

DOI: 10.1016/S0022-3956(00)00022-4

PMID: 11104844

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Abstract

Background: Previous studies suggest that a neural circuit involving over-activation of cortical, paralimbic, limbic, and striatal structures may underlie OCD symptomatology, but results may have been limited by medication use in those studies. To address this, we examined the effects of symptom induction on fMRI neural activation in medication-free patients with OCD. Methods: Seven outpatients with OCD were exposed to individually tailored provocative and innocuous stimuli during fMRI scans. Self-ratings of OCD symptoms were performed prior to each scan and after exposure to stimuli. Images were analyzed as composite data sets and individually. Results: Stimulus presentation was associated with significant increases in OCD self-ratings. Significant activation was demonstrated in several regions of the frontal cortex (orbitofrontal, superior frontal, and the dorsolateral prefrontal); the anterior, medial and lateral temporal cortex; and the right anterior cingulate. Right superior frontal activation inversely correlated with baseline compulsion symptomatology and left orbitofrontal cortical activation was inversely associated with changes in OCD self-ratings following provocative stimuli. Conclusions: These results in unmedicated patients are consistent with those from previous studies with medicated patients and suggest that OCD symptomatology is mediated by multiple brain regions including the anterior cingulate as well as frontal and temporal brain regions.

FMRI

Obsessive–compulsive disorder

Symptom provocation

Details

Title: Subtitle: fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder
Creators: Caleb M Adler - University of Cincinnati Medical Center
Patricia McDonough-Ryan - University of Cincinnati Medical Center
Kenji W Sax - University of Cincinnati Medical Center
Scott K Holland - Cincinnati Children's Hospital Medical Center
Stephan Arndt - University of Iowa
Stephen M Strakowski - University of Cincinnati Medical Center
Resource Type: Journal article
Publication Details: Journal of psychiatric research, Vol.34(4), pp.317-324
DOI: 10.1016/S0022-3956(00)00022-4
PMID: 11104844
NLM abbreviation: J Psychiatr Res
ISSN: 0022-3956
eISSN: 1879-1379
Publisher: Elsevier Ltd
Number of pages: 8
Language: English
Date published: 07/01/2000
Academic Unit: Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
Record Identifier: 9985132071602771

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