Journal article
hAG-2, the Human Homologue of theXenopus laevisCement Gland Gene XAG-2, Is Coexpressed with Estrogen Receptor in Breast Cancer Cell Lines
Biochemical and biophysical research communications, Vol.251(1), pp.111-116
10/09/1998
DOI: 10.1006/bbrc.1998.9440
Abstract
hAG-2, the human homologue of theXenopus laeviscement gland geneXenopusAnterior Gradient-2 (XAG-2), has been found to be coexpressed with estrogen receptor (ER) in breast cancer cell lines by using suppression subtractive hybridization. Sequence analysis of clones obtained from a human breast adenocarcinoma MCF7 cDNA library suggests that at least three mRNA transcripts, differing in their 3′-untranslated regions, are transcribed from the hAG-2 gene. Northern blot analyses identified two principal hAG-2 signals in all ER-positive breast carcinoma cell lines that were absent in cell lines not expressing, or minimally expressing, ER. Coexpression of hAG-2 with ER suggests that hAG-2 may be involved in the tumor biology specific to the well-differentiated phenotype of hormonally-responsive breast cancers.
Details
- Title: Subtitle
- hAG-2, the Human Homologue of theXenopus laevisCement Gland Gene XAG-2, Is Coexpressed with Estrogen Receptor in Breast Cancer Cell Lines
- Creators
- Devon A. Thompson - Stanford UniversityRonald J. Weigel - Stanford University
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.251(1), pp.111-116
- DOI
- 10.1006/bbrc.1998.9440
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 10/09/1998
- Academic Unit
- Molecular Physiology and Biophysics; Anatomy and Cell Biology; Surgery; Biochemistry and Molecular Biology
- Record Identifier
- 9984284325502771
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