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hCG production by mucinous adenocarcinoma of the ovary in a reproductive aged woman
Journal article   Open access   Peer reviewed

hCG production by mucinous adenocarcinoma of the ovary in a reproductive aged woman

Vincent Wagner, Heather Winn, Andreea Newtson, David Bender and Megan McDonald
Gynecologic oncology reports, Vol.26, pp.102-104
11/2018
DOI: 10.1016/j.gore.2018.10.012
PMCID: PMC6258238
PMID: 30533474
url
https://doi.org/10.1016/j.gore.2018.10.012View
Published (Version of record) Open Access

Abstract

When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. Potential sources of hCG include viable intrauterine pregnancy, ectopic pregnancy, miscarriage, gestational trophoblastic disease, pituitary hCG production, phantom hCG (heterophilic antibody interference), and tumor production. Here, we present a case of elevated hCG in a young women with a large complex pelvic mass. Prior to treatment initiation, the patient underwent work up for hCG elevation, which was ultimately found to be from tumor production. Pathologic examination revealed the mass to be a mucinous adenocarcinoma of the ovary with aberrant expression of hCG, rather than the more typical hCG producing germ cell tumor. We detail the preoperative evaluation process of hCG elevation. Additionally, we discuss the role of hCG in ovarian cancer and influence on tumorigenesis and management. •Evaluation of elevated hCG in a premenopausal patient is complex but necessary prior to surgical intervention.•Abberant hCG production resulting in elevated serum hCG can be seen in mucinous adenocarcinomas of the ovary.•hCG production in ovarian cancer may be a useful marker for surveillance.
 Epithelial ovarian cancer hCG Mucinous ovarian adenocarcinoma

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