Journal article
mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients
The Journal of infectious diseases, Vol.226(5), pp.797-807
04/06/2022
DOI: 10.1093/infdis/jiac118
PMCID: PMC9047160
PMID: 35385875
Abstract
Abstract
Background
The study objective was to evaluate 2- and 3-dose coronavirus disease 2019 (COVID-19) mRNA vaccine effectiveness (VE) in preventing COVID-19 hospitalization among adult solid organ transplant (SOT) recipients.
Methods
We conducted a 21-site case-control analysis of 10 425 adults hospitalized in March to December 2021. Cases were hospitalized with COVID-19; controls were hospitalized for an alternative diagnosis (severe acute respiratory syndrome coronavirus 2-negative). Participants were classified as follows: SOT recipient (n = 440), other immunocompromising condition (n = 1684), or immunocompetent (n = 8301). The VE against COVID-19-associated hospitalization was calculated as 1-adjusted odds ratio of prior vaccination among cases compared with controls.
Results
Among SOT recipients, VE was 29% (95% confidence interval [CI], −19% to 58%) for 2 doses and 77% (95% CI, 48% to 90%) for 3 doses. Among patients with other immunocompromising conditions, VE was 72% (95% CI, 64% to 79%) for 2 doses and 92% (95% CI, 85% to 95%) for 3 doses. Among immunocompetent patients, VE was 88% (95% CI, 87% to 90%) for 2 doses and 96% (95% CI, 83% to 99%) for 3 doses.
Conclusions
Effectiveness of COVID-19 mRNA vaccines was lower for SOT recipients than immunocompetent adults and those with other immunocompromising conditions. Among SOT recipients, vaccination with 3 doses of an mRNA vaccine led to substantially greater protection than 2 doses.
Details
- Title: Subtitle
- mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients
- Creators
- Jennie H Kwon - Washington University in St. LouisMark W Tenforde - Centers for Disease Control and PreventionManjusha Gaglani - Scott & White HospitalH Keipp Talbot - Vanderbilt University Medical CenterAdit A Ginde - University of Colorado DenverTresa McNeal - Scott & White HospitalShekhar Ghamande - Scott & White HospitalDavid J Douin - University of Colorado DenverJonathan D Casey - Vanderbilt University Medical CenterNicholas M Mohr - University of IowaAnne Zepeski - University of IowaNathan I Shapiro - Beth Israel Deaconess Medical CenterKevin W Gibbs - Wake Forest UniversityD Clark Files - Wake Forest UniversityDavid N Hager - Johns Hopkins MedicineArber Shehu - Johns Hopkins MedicineMatthew E Prekker - Hennepin County Medical CenterSean D Caspers - Hennepin County Medical CenterMatthew C Exline - The Ohio State UniversityMena Botros - The Ohio State UniversityMichelle N Gong - Albert Einstein College of MedicineAlex Li - Albert Einstein College of MedicineAmira Mohamed - Albert Einstein College of MedicineNicholas J Johnson - University of WashingtonVasisht Srinivasan - University of WashingtonJay S Steingrub - Baystate Medical CenterIthan D Peltan - Intermountain Medical CenterSamuel M Brown - Intermountain Medical CenterEmily T Martin - University of MichiganAkram Khan - Oregon Health & Science UniversityCatherine L Hough - Oregon Health & Science UniversityLaurence W Busse - Emory UniversityAbhijit Duggal - Cleveland ClinicJennifer G Wilson - Stanford UniversityCynthia Perez - Stanford UniversitySteven Y Chang - University of California, Los AngelesChristopher Mallow - Jackson Memorial HospitalRandal Rovinski - Jackson Memorial HospitalHilary M Babcock - Washington University in St. LouisAdam S Lauring - University of MichiganLaura Felley - University of MichiganNatasha Halasa - Vanderbilt University Medical CenterJames D Chappell - Vanderbilt University Medical CenterCarlos G Grijalva - Vanderbilt University Medical CenterTodd W Rice - Vanderbilt University Medical CenterKelsey N Womack - Vanderbilt University Medical CenterChristopher J Lindsell - Vanderbilt University Medical CenterKimberly W Hart - Vanderbilt University Medical CenterAdrienne Baughman - Vanderbilt University Medical CenterSamantha M Olson - Centers for Disease Control and PreventionStephanie Schrag - Centers for Disease Control and PreventionMiwako Kobayashi - Centers for Disease Control and PreventionJennifer R Verani - Centers for Disease Control and PreventionManish M Patel - Centers for Disease Control and PreventionWesley H Self - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.226(5), pp.797-807
- DOI
- 10.1093/infdis/jiac118
- PMID
- 35385875
- PMCID
- PMC9047160
- NLM abbreviation
- J Infect Dis
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: 75D30121F00002; name: Clinical and Translational Science Award, award: UL1 TR002243
- Language
- English
- Date published
- 04/06/2022
- Academic Unit
- Epidemiology; Emergency Medicine; Anesthesia; Injury Prevention Research Center
- Record Identifier
- 9984295914402771
Metrics
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