Journal article
miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes
Communications biology, Vol.5(1), pp.1002-1002
09/21/2022
DOI: 10.1038/s42003-022-03945-1
PMCID: PMC9492679
PMID: 36130994
Abstract
Non-alcoholic fatty liver disease (NAFLD) is associated with hepatic metabolism dysfunction. However, the mechanistic role of miR204 in the development of NAFLD is unknown. We investigate the functional significance of miR204 in the evolution of NAFLD. IDH2 KO mice feed a normal diet (ND) or HFD increased body weight, epididymal fat-pad weight, lipid droplet in liver, blood parameter and inflammation compared to WT mice fed a ND or HFD. Moreover, the expression of miR204 is increased in mice with IDH2 deficiency. Increased miR204 by IDH2 deficiency regulates carnitine palmitoyltransferase 1a (cpt1a) synthesis, which inhibits fatty acid β-oxidation. Inhibition of miR204 prevents the disassembly of two fatty acid-related genes by activating CPT1a expression, which decreases lipid droplet in liver, inflammatory cytokines, epididymal fat pad weight, blood parameters. Increased miR204 by IDH2 deficiency promotes the pathogenesis of HFD-induced NAFLD by regulating hepatic fatty acid metabolism and inflammation.
miR204 is found to inhibit cpt1a in mouse hepatocytes, which could play a role in promoting non-alcoholic fatty liver disease.
Details
- Title: Subtitle
- miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes
- Creators
- Seonhee Kim - Chungnam National UniversityIkjun Lee - Daejeon, 35015 Republic of KoreaShuyu Piao - Daejeon, 35015 Republic of KoreaHarsha Nagar - Daejeon, 35015 Republic of KoreaSu-jeong Choi - Daejeon, 35015 Republic of KoreaYoung-Rae Kim - Iowa City, IA 52242 USAKaikobad Irani - Iowa City, IA 52242 USAByeong Hwa Jeon - Daejeon, 35015 Republic of KoreaCuk-Seong Kim - Daejeon, 35015 Republic of Korea
- Resource Type
- Journal article
- Publication Details
- Communications biology, Vol.5(1), pp.1002-1002
- DOI
- 10.1038/s42003-022-03945-1
- PMID
- 36130994
- PMCID
- PMC9492679
- NLM abbreviation
- Commun Biol
- eISSN
- 2399-3642
- Publisher
- Nature Publishing Group UK
- Grant note
- NRF-2014R1A6A1029617 / ;
- Language
- English
- Date published
- 09/21/2022
- Academic Unit
- Cardiovascular Medicine; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984312980902771
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