Journal article
microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families
Biomedical reports, Vol.2(3), pp.384-387
05/01/2014
DOI: 10.3892/br.2014.239
PMCID: PMC3990207
PMID: 24748979
Abstract
microRNAs (miRNAs) are involved in almost all normal and pathogenic eukaryotic cell processes. One area in which the influence of miRNAs is most prominent is cancer. Numerous expression surveys and more focused studies have revealed miRNA involvement in carcinogenesis, cellular pathology, cell behavior and prognosis. Large-scale comparisons of miRNA expression in varioius types of cancer have not been previously possible. However, The Cancer Genome Atlas (TCGA), an extensive multi-centered effort to characterize the genomes of hundreds of types of cancer, has enabled such comparisons. In the present study, the expression patterns of hundreds of miRNAs in thousands of tumors covering seven types of cancer: uterine corpus adenocarcinoma, ovarian serous adenocarcinoma, breast adenocarcinoma, prostate adenocarcinoma, pancreatic adenocarcinoma, colorectal adenocarcinoma, and lung adenocarcinoma were analyzed. The results showed that miRNA expression patterns among these cancer types are highly correlated (0.874>(sic)> 0.974) and that miRNA expression in all seven cancer types is dominated by miRNAs belonging to the most evolutionarily ancient miRNA families. This raises the possibility that more ancient miRNAs are involved in the fundamental cell processes that are central to tumor evolution.
Details
- Title: Subtitle
- microRNA expression patterns across seven cancers are highly correlated and dominated by evolutionarily ancient families
- Creators
- Eric J. Devor - Roy J. and Lucille A. Carver College of MedicineBrandon M. Schickling - University of IowaKimberly K. Leslie - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biomedical reports, Vol.2(3), pp.384-387
- DOI
- 10.3892/br.2014.239
- PMID
- 24748979
- PMCID
- PMC3990207
- NLM abbreviation
- Biomed Rep
- ISSN
- 2049-9434
- eISSN
- 2049-9442
- Publisher
- Spandidos Publ Ltd
- Number of pages
- 4
- Grant note
- R01CA099908 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) RO1CA99908 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Department of Obstetrics and Gynecology Research Development Fund
- Language
- English
- Date published
- 05/01/2014
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984316898102771
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