Journal article
n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
Diabetes care, Vol.44(5), pp.1133-1142
03/03/2021
DOI: 10.2337/dc20-2426
PMCID: PMC8132316
PMID: 33658295
Abstract
OBJECTIVE Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of a-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance–weighted meta-analysis. RESULTS A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS Highercirculating biomarkers of seafood-derivedn-3 fattyacids, including EPA,DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.
Details
- Title: Subtitle
- n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies
- Creators
- Frank Qian - Harvard UniversityAndres V. Ardisson Korat - Brigham and Women's HospitalFumiaki Imamura - University of CambridgeMatti Marklund - Tufts UniversityNathan Tintle - Dordt UniversityJyrki K. Virtanen - University of Eastern FinlandXia Zhou - University of MinnesotaJulie K. Bassett - Cancer Council VictoriaHeidi Lai - Tufts UniversityYoichiro Hirakawa - Kyushu UniversityKuo-Liong Chien - National Taiwan UniversityAlexis C. Wood - Children’s Nutrition Research Center, U.S. Department of Agriculture/Agricultural Research Service, Houston, TXMaria Lankinen - University of Eastern FinlandRachel A. Murphy - University of British ColumbiaCecilia Samieri - Bordeaux Population HealthKamalita Pertiwi - Wageningen University & ResearchVanessa D. de Mello - University of Eastern FinlandWeihua Guan - University of MinnesotaNita G. Forouhi - University of CambridgeNick Wareham - University of CambridgeFrank B Hu - Brigham and Women's HospitalUlf Riserus - Uppsala UniversityLars Lind - Uppsala UniversityWilliam S. Harris - University of South DakotaAladdin H. Shadyab - University of California - San Diego School of MedicineJennifer G. Robinson - University of IowaLyn M. Steffen - University of Eastern FinlandAllison Hodge - University of MelbourneGraham G. Giles - Monash UniversityToshiharu Ninomiya - Kyushu UniversityMatti Uusitupa - 10Fatty Acid Research Institute, Sioux Falls, SDJaakko Tuomilehto - Finnish Institute for Health and WelfareJaana Lindström - Finnish Institute for Health and WelfareMarkku Laakso - University of Eastern FinlandDavid S. Siscovick - New York Academy of MedicineCatherine Helmer - University of British ColumbiaJohanna M. Geleijnse - Bordeaux Population HealthJason H.Y. Wu - George Institute for Global HealthAmanda Fretts - University of WashingtonRozenn N. Lemaitre - University of WashingtonRenata Micha - Tufts UniversityDariush Mozaffarian - Tufts Medical CenterQi Sun - Brigham and Women's HospitalInterAct Consortium
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.44(5), pp.1133-1142
- Publisher
- American Diabetes Association
- DOI
- 10.2337/dc20-2426
- PMID
- 33658295
- PMCID
- PMC8132316
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- R01HL034594; R01HL088521
- Language
- English
- Date published
- 03/03/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363577802771
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