Journal article
p16(INK4A) expression in invasive laryngeal cancer
Papillomavirus research, Vol.2, pp.52-55
12/2016
DOI: 10.1016/j.pvr.2016.03.001
PMCID: PMC5637278
PMID: 29034342
Abstract
We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA.
Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively. Positivity for p16 and/or HPV DNA was not associated with 5-year survival (log-rank p value=0.55). Our findings support a limited role of HPV in laryngeal carcinogenesis. p16 is not a reliable surrogate for HPV status in laryngeal cancers and is not a predictor of laryngeal cancer survival.
Details
- Title: Subtitle
- p16(INK4A) expression in invasive laryngeal cancer
- Creators
- Brenda Y Hernandez - University of Hawaii Cancer Center, 701 Ilalo Street #239, Honolulu, HI 96813, USAMobeen Rahman - University of Hawaii John A. Burns School of Medicine, 651 Ilalo Street #411E, Honolulu, HI 96813, USACharles F Lynch - The University of Iowa, College of Public Health, Department of Epidemiology, 145 North Riverside Drive S447 CPHB, Iowa City, IA 52242-2007, USAWendy Cozen - University of Southern California, Norris Comprehensive Cancer Center and Keck School of Medicine, Departments of Preventive Medicine and Pathology, 1441 Eastlake Avenue MC 9175, Los Angeles, CA 90089-9175, USAElizabeth R Unger - Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, GA 30329-4027, USAMartin Steinau - Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, GA 30329-4027, USATrevor Thompson - Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F-76, Atlanta, GA 30341-3717, USAMaria Sibug Saber - University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue #4420, Los Angeles, CA 90089-9175, USASean F Altekruse - National Cancer Institute, Surveillance Research Program, 9609 Medical Center Drive, Room 4E536, Rockville, MD 20850, USAMarc T Goodman - Cedars-Sinai Medical Center, 8700 Beverly Blvd, Room 1S37, Los Angeles, CA 90048, USAAmy Powers - The Queen׳s Medical Center, Department of Pathology, 1301 Punchbowl St., Iolani 4, Honolulu, HI 96813, USAChristopher Lyu - Battelle, 100 Capitola Drive, Suite 200, Durham, NC 27713, USAMona Saraiya - Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341-3717, USAHPV Typing of Cancer Workgroup
- Resource Type
- Journal article
- Publication Details
- Papillomavirus research, Vol.2, pp.52-55
- DOI
- 10.1016/j.pvr.2016.03.001
- PMID
- 29034342
- PMCID
- PMC5637278
- NLM abbreviation
- Papillomavirus Res
- ISSN
- 2405-8521
- eISSN
- 2405-8521
- Publisher
- Elsevier B.V
- Language
- English
- Date published
- 12/2016
- Academic Unit
- Epidemiology
- Record Identifier
- 9984214841902771
Metrics
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