Journal article
p16INK4a Expression, human papillomavirus, and survival in head and neck cancer
Oral oncology, Vol.44(2), pp.133-142
02/2008
DOI: 10.1016/j.oraloncology.2007.01.010
PMID: 17360226
Abstract
Development of head and neck cancer (HNC) is associated with human papillomavirus high-risk (HPV-HR) types. The HPV E7 oncoprotein inactivates the pRB protein increasing expression of p16INK4a. p16 Expression and HPV status have been associated with differences in clinical outcomes for HNC. This study examined whether HNC prognosis was different when these biomarkers were examined as individual or joint molecular effects. Tumor tissue from 301 HNC patients were analyzed and sequenced for HPV types. p16 was evaluated by immunohistochemical staining. p16 was expressed in 35% and HPV-HR was detected in 27% of HNC patients. After adjustment for age, tobacco, and alcohol, p16+ tumors were statistically significantly associated with HPV-HR (OR=13.3, 7.1–24.9), histology, stage, grade, tumor site, and node involvement. Compared to p16+ HNC cases, those who did not express p16 had significantly worse disease-specific (DS) survival (Hazards Ratio, adj.HR=2.0. 1.0–3.9) and recurrence (adj.HR=3.6, 1.6–8.2); and HPV− cases had worse DS survival (adj.HR=2.8, 1.1–7.1) and recurrence (adj.HR=2.0, 0.8–4.8) compared to HPV-HR patients. Each of the p16/HPV groups had different survival outcomes: p16+/HPV-HR cases (referent) had the best and p16−/HPV− cases had the worst DS survival (adj.HR=3.6; 53% versus 13%, p=0.004) whereas p16+/HPV− and p16−/HPV-HR had similar DS survival (adj.HR=2.7/2.8). p16−/HPV-HR cases had a worse recurrence rate (adj.HR=7.0; 60% versus 0%, referent, p=0.08) than p16−/HPV− (adj.HR=4.5) or p16+/HPV− (adj.HR=1.8) cases. The combined p16/HPV biomarker data are associated with different survival outcomes of HNC compared to each marker evaluated separately, indicating that the two molecular mechanisms evaluated together may provide a more accurate prediction of clinical outcomes.
Details
- Title: Subtitle
- p16INK4a Expression, human papillomavirus, and survival in head and neck cancer
- Creators
- Elaine M Smith - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesDonghong Wang - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesYoonsang Kim - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesLinda M Rubenstein - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, United StatesJohn H Lee - Department of Otolaryngology, College of Medicine, University of Iowa, Iowa City, IA 52242, United StatesThomas H Haugen - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, United StatesLubomir P Turek - Veterans Affairs Medical Center and Department of Pathology, College of Medicine, University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Oral oncology, Vol.44(2), pp.133-142
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.oraloncology.2007.01.010
- PMID
- 17360226
- ISSN
- 1368-8375
- eISSN
- 1879-0593
- Language
- English
- Date published
- 02/2008
- Academic Unit
- Epidemiology; Pathology; Otolaryngology; Internal Medicine
- Record Identifier
- 9984047891402771
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