p185neu expression in human lung adenocarcinomas predicts shortened survival

Jeffrey A. Kern; David A. Schwartz; J E Nordberg; David B Weiner; M I Greene; L Torney; R A Robinson

Back

p185neu expression in human lung adenocarcinomas predicts shortened survival

Journal article

Peer reviewed

p185neu expression in human lung adenocarcinomas predicts shortened survival

Jeffrey A. Kern, David A. Schwartz, J E Nordberg, David B Weiner, M I Greene, L Torney and R A Robinson

Cancer research (Chicago, Ill.), Vol.50(16), pp.5184-5191

08/15/1990

PMID: 1974168

View Online

Abstract

p185neu is the protein product of the HER2/neu protooncogene. This protein has characteristics of a tyrosine kinase growth factor receptor and is postulated to be important in human carcinogenesis. To define the significance of the expression of this protein in human non-small cell lung cancer, 55 tumors from patients with squamous cell carcinoma (16), adenocarcinoma (29), or large cell carcinoma (10) of the lung were examined for p185neu using immunohistological methods. Five of 16 squamous cell carcinomas and 10 of 29 adenocarcinomas were found to overexpress p185neu relative to levels of expression seen in uninvolved bronchiolar epithelium. For the adenocarcinomas, p185neu expression was associated with older age (66.6 +/- 10.1 versus 57.5 +/- 10.8 years) (P = 0.04) and shortened survival (83.7 +/- 94.1 versus 188.5 +/- 120 weeks) (P = 0.01). In this group, using Cox's multivariate survival analysis, p185neu expression was found to be a significant determinant of survival (P = 0.04) even after accounting for the effect of tumor stage. For the squamous cell carcinomas, p185neu expression was not correlated with any of our clinicopathological parameters. Our findings indicate that non-small cell lung cancers which express p185neu do so at levels higher than that found in normal bronchiolar epithelium, and expression in adenocarcinomas of the lung is independently associated with diminished survival intervals.

Lung Neoplasms - genetics

Cell Line

Adenocarcinoma - pathology

Prognosis

Immune Sera

Biomarkers, Tumor - analysis

Humans

Lung Neoplasms - pathology

Male

Proto-Oncogene Proteins - genetics

Proto-Oncogenes

Ploidies

Proto-Oncogene Proteins - analysis

Female

Adenocarcinoma - genetics

Receptor, ErbB-2

Tumor Cells, Cultured - cytology

Smoking

Details

Title: Subtitle: p185neu expression in human lung adenocarcinomas predicts shortened survival
Creators: Jeffrey A. Kern - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
David A. Schwartz
J E Nordberg
David B Weiner
M I Greene
L Torney
R A Robinson
Resource Type: Journal article
Publication Details: Cancer research (Chicago, Ill.), Vol.50(16), pp.5184-5191
Publisher: United States
PMID: 1974168
ISSN: 0008-5472
eISSN: 1538-7445
Grant note: HL01575 / NHLBI NIH HHS
Language: English
Date published: 08/15/1990
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology
Record Identifier: 9984046922302771

Metrics

11 Record Views

453 Times Cited - Web of Science