Journal article
p53 Acetylation: Regulation and Consequences
Cancers, Vol.7(1), pp.30-69
12/23/2014
DOI: 10.3390/cancers7010030
PMCID: PMC4381250
PMID: 25545885
Abstract
Post-translational modifications of p53 are critical in modulating its tumor suppressive functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular localization and transcriptional vs. non-transcriptional activities. Less is known about p53 acetylation. It has been shown to govern p53 transcriptional activity, selection of growth inhibitory vs. apoptotic gene targets, and biological outcomes in response to diverse cellular insults. Yet recent in vivo evidence from mouse models questions the importance of p53 acetylation (at least at certain sites) as well as canonical p53 functions (cell cycle arrest, senescence and apoptosis) to tumor suppression. This review discusses the cumulative findings regarding p53 acetylation, with a focus on the acetyltransferases that modify p53 and the mechanisms regulating their activity. We also evaluate what is known regarding the influence of other post-translational modifications of p53 on its acetylation, and conclude with the current outlook on how p53 acetylation affects tumor suppression. Due to redundancies in p53 control and growing understanding that individual modifications largely fine-tune p53 activity rather than switch it on or off, many questions still remain about the physiological importance of p53 acetylation to its role in preventing cancer.
Details
- Title: Subtitle
- p53 Acetylation: Regulation and Consequences
- Creators
- Sara M Reed - Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. sara-reed@uiowa.eduDawn E Quelle - Department of Pharmacology, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. dawn-quelle@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.7(1), pp.30-69
- DOI
- 10.3390/cancers7010030
- PMID
- 25545885
- PMCID
- PMC4381250
- NLM abbreviation
- Cancers (Basel)
- ISSN
- 2072-6694
- eISSN
- 2072-6694
- Publisher
- Switzerland
- Grant note
- T32 GM067795 / NIGMS NIH HHS T32 GM007337 / NIGMS NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 12/23/2014
- Academic Unit
- Pathology; Neuroscience and Pharmacology
- Record Identifier
- 9984040233302771
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