Journal article
p53 as Exemplar Next-Generation Immunohistochemical Marker: A Molecularly Informed, Pattern-Based Approach, Methodological Considerations, and Pan-Cancer Diagnostic Applications
Applied immunohistochemistry & molecular morphology, Vol.31(7), pp.507-530
08/2023
DOI: 10.1097/PAI.0000000000001144
PMID: 37471633
Abstract
This review is based on a webinar I presented for the International Society for Immunohistochemistry and Molecular Morphology (ISIMM) in February 2022. It is intended that all ISIMM webinars will ultimately be published in AIMM as review articles. This work is also dedicated to Clive Taylor, who has deeply impacted my career. It presents a molecularly informed, pattern-based approach to p53 immunohistochemistry interpretation, methodological considerations (ie, antibody selection, optimization, validation, controls, and external quality assessment), and pan-cancer diagnostic applications, including those drawn from gastrointestinal, genitourinary, gynecological, neuroendocrine, hematologic, and neuropathology. It intends to prove the thesis statement that p53 is an exemplar next-generation immunohistochemical marker "born" ahead of its time.
Details
- Title: Subtitle
- p53 as Exemplar Next-Generation Immunohistochemical Marker: A Molecularly Informed, Pattern-Based Approach, Methodological Considerations, and Pan-Cancer Diagnostic Applications
- Creators
- Andrew M. Bellizzi
- Resource Type
- Journal article
- Publication Details
- Applied immunohistochemistry & molecular morphology, Vol.31(7), pp.507-530
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/PAI.0000000000001144
- PMID
- 37471633
- ISSN
- 1541-2016
- eISSN
- 1533-4058
- Grant note
- NIH: P50 CA174521-01A1
Supported by NIH grant P50 CA174521-01A1 (A.M.B.)
- Language
- English
- Date published
- 08/2023
- Academic Unit
- Pathology
- Record Identifier
- 9984810944002771
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