Journal article
p53, proliferating cell nuclear antigen, and Ki-67 expression in extrauterine leiomyosarcomas
Modern pathology, Vol.10(2), pp.91-97
02/1997
PMID: 9127313
Abstract
Extrauterine leiomyosarcomas, because of their relative rarity, are poorly understood in regards to their malignant potential and biologic markers. Many human tumors are characterized by overexpression of p53, a tumor suppressor protein, and by expression of nuclear proteins associated with proliferation, such as proliferating cell nuclear antigen (PCNA) and Ki-67. We examined expression of these markers in 44 extrauterine leiomyosarcomas from 10 men and 25 women who ranged in age from 25 to 82 years (mean, 56 yr). Clinical follow-up was obtained in 34 (97%) of 35 patients, p53 expression was studied with two monoclonal antibodies (1801, D07) by use of an antigen retrieval method. p53 overexpression was present in 19 (43%) of 44 cases, whereas Ki-67 and PCNA staining were seen in 29 (66%) and 36 (82%) of 44 cases, respectively. There was no correlation between overall survival or recurrence and p53 or PCNA and Ki-67 expression. We conclude that p53, Ki-67, and PCNA are expressed in a large number of extrauterine leiomyosarcomas. In this study, the expression of these markers did not predict biologic behavior.
Details
- Title: Subtitle
- p53, proliferating cell nuclear antigen, and Ki-67 expression in extrauterine leiomyosarcomas
- Creators
- P E O'Reilly - Department of Pathology, Eglin Air Force Base, Florida, USAS S RaabT H NiemannJ R RodgersR A Robinson
- Resource Type
- Journal article
- Publication Details
- Modern pathology, Vol.10(2), pp.91-97
- Publisher
- United States
- PMID
- 9127313
- ISSN
- 0893-3952
- eISSN
- 1530-0285
- Language
- English
- Date published
- 02/1997
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology
- Record Identifier
- 9984047756402771
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