p63 Expression in Olfactory Neuroblastoma and Other Small Cell Tumors of the Sinonasal Tract

T. David BOURNE; Andrew M BELLIZZI; Edward B STELOW; Andrew H LOY; Paul A LEVINE; Mark R WICK; Stacey E MILLS

doi:10.1309/TEDD2FCWH8W0H4HA

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p63 Expression in Olfactory Neuroblastoma and Other Small Cell Tumors of the Sinonasal Tract

Journal article

Open access

Peer reviewed

p63 Expression in Olfactory Neuroblastoma and Other Small Cell Tumors of the Sinonasal Tract

T. David BOURNE, Andrew M BELLIZZI, Edward B STELOW, Andrew H LOY, Paul A LEVINE, Mark R WICK and Stacey E MILLS

American journal of clinical pathology, Vol.130(2), pp.213-218

2008

DOI: 10.1309/TEDD2FCWH8W0H4HA

PMID: 18628089

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Abstract

Olfactory neuroblastoma (ONB) is a rare neoplasm of the head and neck region that is included in the differential diagnosis of other sinonasal tract malignancies. We studied the usefulness of using p63 as an aid in the diagnosis of ONB and other tumors of the sinonasal region. The specimens were 14 ONBs; 4 nasopharyngeal carcinomas (NPCs), nonkeratinizing subtype; 2 NPCs, undifferentiated subtype; 10 sinonasal undifferentiated carcinomas (SNUCs); 7 malignant melanomas; and 2 extranodal natural killer (NK)/T-cell lymphomas. We observed p63 expression in 5 ONBs (36%), 4 nonkeratinizing NPCs (100%), 1 undifferentiated NPC (50%), 2 SNUCs (20%); 0 malignant melanomas (0%); and 1 extranodal NK/T-cell lymphoma (50%). While all cases of NPC with positive staining for p63 showed strong and diffuse immunoreactivity, the ONB, SNUC, and lymphoma cases with positive immunoreactivity showed only focal staining for p63. No p63 expression was observed in malignant melanoma. We think p63 is a useful marker to help distinguish nonkeratinizing or undifferentiated NPC subtypes from various sinonasal tract malignancies. In particular, p63 helps distinguish nonkeratinizing and undifferentiated NPC subtypes from SNUC.

Tumors

Investigative techniques, diagnostic techniques (general aspects)

Otorhinolaryngology. Stomatology

Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques

Biological and medical sciences

Medical sciences

Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology

Details

Title: Subtitle: p63 Expression in Olfactory Neuroblastoma and Other Small Cell Tumors of the Sinonasal Tract
Creators: T. David BOURNE - Robert E. Fechner Surgical Pathology Laboratory, University of Virginia, Charlottesville, United States
Andrew M BELLIZZI - Robert E. Fechner Surgical Pathology Laboratory, University of Virginia, Charlottesville, United States
Edward B STELOW - Robert E. Fechner Surgical Pathology Laboratory, University of Virginia, Charlottesville, United States
Andrew H LOY - Department of Otorhinolaryngology, Tan Tock Seng Hospital, Singapore
Paul A LEVINE - Department of Otolaryngology-Head and Neck Surgery, Division of Head and Neck Surgical Oncology, University of Virginia, Charlottesville, United States
Mark R WICK - Robert E. Fechner Surgical Pathology Laboratory, University of Virginia, Charlottesville, United States
Stacey E MILLS - Robert E. Fechner Surgical Pathology Laboratory, University of Virginia, Charlottesville, United States
Resource Type: Journal article
Publication Details: American journal of clinical pathology, Vol.130(2), pp.213-218
Publisher: American Society of Clinical Pathologists; Chicago, IL
DOI: 10.1309/TEDD2FCWH8W0H4HA
PMID: 18628089
ISSN: 0002-9173
eISSN: 1943-7722
Language: English
Date published: 2008
Academic Unit: Pathology
Record Identifier: 9984047779802771

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