Journal article
p66Shc-a longevity redox protein in human prostate cancer progression and metastasis
Cancer and metastasis reviews, Vol.29(1), pp.207-222
03/01/2010
DOI: 10.1007/s10555-010-9213-8
PMCID: PMC2909029
PMID: 20111892
Abstract
p66Shc, a 66 kDa proto-oncogene Src homologous-collagen homologue (Shc) adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and recently identified as a sensor to oxidative stress-induced apoptosis and as a longevity protein in mammals. The expression of p66Shc is decreased in mice and increased in human fibroblasts upon aging and in aging-related diseases, including prostate cancer. p66Shc protein level correlates with the proliferation of several carcinoma cells and can be regulated by steroid hormones. Recent advances point that p66Shc protein plays a role in mediating cross-talk between steroid hormones and redox signals by serving as a common convergence point in signaling pathways on cell proliferation and apoptosis. This article first reviews the unique function of p66Shc protein in regulating oxidative stress-induced apoptosis. Subsequently, we discuss its novel role in androgen-regulated prostate cancer cell proliferation and metastasis and the mechanism by which it mediates androgen action via the redox signaling pathway. The data together indicate that p66Shc might be a useful biomarker for the prognosis of prostate cancer and serve as an effective target for its cancer treatment.
Details
- Title: Subtitle
- p66Shc-a longevity redox protein in human prostate cancer progression and metastasis
- Creators
- Mythilypriya Rajendran - University of Nebraska Medical CenterPaul Thomes - University of Nebraska Medical CenterLi Zhang - University of Nebraska Medical CenterSuresh Veeramani - University of Nebraska Medical CenterMing-Fong Lin - University of Nebraska Medical Center
- Resource Type
- Journal article
- Publication Details
- Cancer and metastasis reviews, Vol.29(1), pp.207-222
- DOI
- 10.1007/s10555-010-9213-8
- PMID
- 20111892
- PMCID
- PMC2909029
- NLM abbreviation
- Cancer Metastasis Rev
- ISSN
- 0167-7659
- eISSN
- 1573-7233
- Publisher
- Springer Nature
- Number of pages
- 16
- Grant note
- 2008-20; 2010-18 / Nebraska Cancer and Smoking Disease Research Program W81XWH-06-1-0070; W81XWH-081-0459 / Department of Defense; United States Department of Defense R01CA088184 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01 CA88184 / National Cancer Institute, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Nebraska Research Initiative for Cancer Metastasis
- Language
- English
- Date published
- 03/01/2010
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359808202771
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