Journal article
pKa of fentanyl varies with temperature: implications for acid-base management during extremes of body temperature
Journal of cardiothoracic and vascular anesthesia, Vol.19(6), pp.759-762
12/01/2005
DOI: 10.1053/j.jvca.2004.11.039
PMID: 16326301
Abstract
OBJECTIVEThe pKa of fentanyl has not been measured previously at varying extremes of body temperature. The goal of this laboratory investigation was to test the hypothesis that the pKa of fentanyl changes with temperature.DESIGNThe investigation involved measuring the pKa values of aqueous fentanyl at varying temperatures.SETTINGThe investigation was conducted in a controlled laboratory environment.PARTICIPANTSNo human or animal subjects were involved.INTERVENTIONSBecause no live subjects were involved in the investigation, no interventions were necessary.MEASUREMENTS AND MAIN RESULTSThis paper reports the effect of temperature on the pKa of fentanyl. The pKa of aqueous fentanyl was measured at 15 degrees C, 25 degrees C, 37 degrees C, 42 degrees C, and 47.5 degrees C by potentiometric titration in 0.01 mmol/L of potassium chloride after extensive degassing. Data were analyzed using the least squares method with an appropriately fitting equation. The pKa of fentanyl was found to change in a similar manner to the neutral point of water at varying temperatures.CONCLUSIONSThis finding has implications for the bioavailability of fentanyl at extremes of body temperature in association with the clinical acid-base management of the patient. Clinical implications for differing methods of intraoperative acid-base management at varying temperatures are discussed.
Details
- Title: Subtitle
- pKa of fentanyl varies with temperature: implications for acid-base management during extremes of body temperature
- Creators
- Richard L Thurlkill - Texas A&M UniversityDavid A Cross - Scott & White HospitalJ Martin Scholtz - Texas A&M UniversityC Nick Pace - Texas A&M University
- Resource Type
- Journal article
- Publication Details
- Journal of cardiothoracic and vascular anesthesia, Vol.19(6), pp.759-762
- DOI
- 10.1053/j.jvca.2004.11.039
- PMID
- 16326301
- ISSN
- 1053-0770
- eISSN
- 1532-8422
- Language
- English
- Date published
- 12/01/2005
- Academic Unit
- Research Administration; Pharmaceutical Sciences and Experimental Therapeutics; Biochemistry and Molecular Biology; Chemistry
- Record Identifier
- 9984288729802771
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