t(14;18) Translocations and risk of follicular lymphoma

Charles S Rabkin; Carsten Hirt; Siegfried Janz; Gottfried Dölken

doi:10.1093/jncimonographs/lgn002

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t(14;18) Translocations and risk of follicular lymphoma

Journal article

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t(14;18) Translocations and risk of follicular lymphoma

Charles S Rabkin, Carsten Hirt, Siegfried Janz and Gottfried Dölken

Journal of the National Cancer Institute. Monographs, Vol.2008(39), pp.48-51

2008

DOI: 10.1093/jncimonographs/lgn002

PMCID: PMC6948841

PMID: 18648003

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https://doi.org/10.1093/jncimonographs/lgn002View

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Abstract

The chromosomal translocation t(14;18)(q32;q21) is characteristic of follicular lymphoma and a frequent abnormality in other types of non-Hodgkin lymphoma (NHL). In healthy individuals, the same translocation may also be found in a small fraction of peripheral blood lymphocytes, the biological significance of which is beginning to be explored. Translocation prevalence and frequency are potential risk factors for developing NHL. Here, we review the published data and describe recent and ongoing work on this promising biomarker. We have a series of studies in four major areas: 1) t(14;18) prevalence and frequency in healthy individuals; 2) maturation of translocation-harboring cells; 3) effect of rituximab treatment on t(14;18) carriage; and 4) predictive and clonotypic relationship between t(14;18) and follicular lymphoma or other NHL. Further studies are warranted to increase understanding of this crucial molecular event in the development of hematopoietic malignancies. Potential applications include determination of elevated risk for lymphoma, early detection of disease, and identification of molecular targets for preventive interventions.

Translocation, Genetic

Lymphoma, Follicular - genetics

Chromosomes, Human, Pair 18 - genetics

Humans

Risk Factors

Chromosomes, Human, Pair 14 - genetics

Details

Title: Subtitle: t(14;18) Translocations and risk of follicular lymphoma
Creators: Charles S Rabkin - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. rabkinc@mail.nih.gov
Carsten Hirt
Siegfried Janz
Gottfried Dölken
Resource Type: Journal article
Publication Details: Journal of the National Cancer Institute. Monographs, Vol.2008(39), pp.48-51
DOI: 10.1093/jncimonographs/lgn002
PMID: 18648003
PMCID: PMC6948841
ISSN: 1052-6773
eISSN: 1745-6614
Grant note: Z01 BC010024 / Intramural NIH HHS ZIA CP010150 / Intramural NIH HHS
Language: English
Date published: 2008
Academic Unit: Pathology
Record Identifier: 9984083869202771

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