Journal article
αβ and γδ T-cell networks and their roles in natural resistance to viral infections
Immunological reviews, Vol.159(1), pp.79-93
10/1997
DOI: 10.1111/j.1600-065X.1997.tb01008.x
PMID: 9416504
Abstract
Both αβ and γδ T-cell populations and natural killer (NK) cells include cytotoxic, interferon (IFN)-γ-producing lymphocytes that actively respond to viral infections. We show here that all three populations can provide “natural resistance“ of viruses very early in infection and describe how the T-tell populations are modulated TO provide this function. γδ T cells were shown to play a role in controlling vaccinia virus (VV) infections, as VV grew to much higher titers in γδ T-cell knockout mice than in normal mice 3–4 days post-infection. Our studies of the of T-cell responses to viruses revealed an interactive network of T cells that is modulated substantially during systemic infections. There is an induction phase associated with a massive virus-specific CD8 T-cell response, an apoptosis phase during which the T cells become sensitized to activation-induced ceil death (AICD). a silencing phase, during which the T-cell number and activation state is reduced, and. finally, a memory phase associated with the very stable preservation of virus-specific memory cytotoxic T-lymphocyte precursors (pCTL). Infection of mice immune to one-H US with a heterologous virus leads to a selective expansion of memory CTL cross-reacting between the two viruses, but, after homeostasis is again established, there is a quantitative reduction and quantitative alteration of memory to the first virus. Our results suggest that memory of T cells cross-reactive between heterologous viruses mediate both immunopathology and protective immunity at early stages of the second viruses infection. Thus, memory αβ T cells can, like γδ T cells and NK cells, provide natural immunity to viral infections.
Details
- Title: Subtitle
- αβ and γδ T-cell networks and their roles in natural resistance to viral infections
- Creators
- Raymond M Welsh - Department of Pathology, University of Massachusetts Medical Center, Worcester 01655, USA. RWelsh@Bangate.ummed.eduMeei-Yun LinBarbara L LohmanSteven M VargaChristopher C. ZarozinskiLiisa K Selin
- Resource Type
- Journal article
- Publication Details
- Immunological reviews, Vol.159(1), pp.79-93
- DOI
- 10.1111/j.1600-065X.1997.tb01008.x
- PMID
- 9416504
- NLM abbreviation
- Immunol Rev
- ISSN
- 0105-2896
- eISSN
- 1600-065X
- Grant note
- AI17672 / NIAID NIH HHS AR35506 / NIAMS NIH HHS CA34461 / NCI NIH HHS
- Language
- English
- Date published
- 10/1997
- Academic Unit
- Graduate College Admin and Gen; Microbiology and Immunology; Pathology
- Record Identifier
- 9984083222702771
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