Journal article
β 2-microglobulin, HIV-1 p24 antibody and acid-dissociated HIV-1 p24 antigen levels: predictive markers for vertical transmission of HIV-1 in pregnant Ugandan women
AIDS (London), Vol.7(11), pp.1475-1479
11/1993
DOI: 10.1097/00002030-199311000-00011
PMID: 8280414
Abstract
To evaluate the clinical utility of plasma beta 2-microglobulin (beta 2M) levels, acid-dissociated HIV-1 p24 antigen, and HIV-1 p24-antibody titers in predicting HIV-1 vertical transmission in 227 HIV-1-infected Ugandan pregnant women.
Plasma beta 2M levels, acid-dissociated HIV-1 p24-antigen positivity, and HIV-1 p24-antibody titers were determined using commercial enzyme immunoassays (EIA) in a Ugandan cohort of 52 HIV-1-seropositive transmitting mothers, 175 HIV-1-seropositive non-transmitting mothers, and 52 seronegative mothers within 6 weeks prior to delivery.
Transmitter mothers had significantly higher plasma concentrations of beta 2M (1.80 +/- 1.13 mg/l) than non-transmitter seropositive mothers (1.32 +/- 0.81 mg/l; P = 0.0013). Similarly, a significantly higher proportion of transmitter mothers had detectable p24 antigen than non-transmitter mothers [six out of 51 (11.8%) versus six out of 173 (3.5%); P = 0.03]. Compared with the vertical transmission rate of 23% in the seropositive group, the positive predictive values of a beta 2M level > 1.5 mg/l or detectable HIV-1 p24 antigen for vertical transmission were 34 and 50%, respectively. Five of six (83.3%) seropositive mothers with both a beta 2M level > 1.5 mg/l and detectable p24 antigenemia transmitted HIV-1 infection to their infants compared with 25 of 124 (20.2%) seropositive mothers with values below the cut-off values for both tests (P = 0.00249). However, beta 2M was not found to be a significant independent predictor of vertical transmission when analyzed in a multivariate model with p24 antigenemia. There was no significant difference in HIV-1 p24-antibody titers in transmitter mothers versus non-transmitter mothers (P = 0.299).
beta 2M levels and acid-dissociated HIV-1 p24-antigen assays may be used to predict which HIV-1-infected pregnant women are at greatest risk for vertical transmission. However, only the p24-antigen test was independently predictive of vertical transmission and its clinical utility is limited.
Details
- Title: Subtitle
- β 2-microglobulin, HIV-1 p24 antibody and acid-dissociated HIV-1 p24 antigen levels: predictive markers for vertical transmission of HIV-1 in pregnant Ugandan women
- Creators
- J Brooks Jackson - Department of Pathology, Case Western Reserve University, Cleveland, OH 44106Peter KataahaDavid L HomFrancis MmiroLaura GuayCristopher NdugwaLawrence MarumEstelle PiwowarKaren BrewerGary ToedterDavid HofheinzKaren Olness
- Resource Type
- Journal article
- Publication Details
- AIDS (London), Vol.7(11), pp.1475-1479
- Publisher
- England
- DOI
- 10.1097/00002030-199311000-00011
- PMID
- 8280414
- ISSN
- 0269-9370
- eISSN
- 1473-5571
- Grant note
- NIAID AI-25879 / NIAID NIH HHS NIAID R01-AI-26482-03 / NIAID NIH HHS NIAID R01-AI-32395 / NIAID NIH HHS
- Language
- English
- Date published
- 11/1993
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047721002771
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