β2-Adrenergic agonist regulation of immune aggregate- and platelet-activating factor-stimulated hepatic metabolism

Mark E Steinhelper; Rory A Fisher; G E Revtyak; Donald J Hanahan; M S Olson

doi:10.1016/S0021-9258(18)60414-4

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β2-Adrenergic agonist regulation of immune aggregate- and platelet-activating factor-stimulated hepatic metabolism

Journal article

Open access

Peer reviewed

β2-Adrenergic agonist regulation of immune aggregate- and platelet-activating factor-stimulated hepatic metabolism

Mark E Steinhelper, Rory A Fisher, G E Revtyak, Donald J Hanahan and M S Olson

The Journal of biological chemistry, Vol.264(19), pp.10976-10981

07/05/1989

DOI: 10.1016/S0021-9258(18)60414-4

PMID: 2544577

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Abstract

Vasoconstriction and subsequent glycogenolysis stimulated by immune complex infusion into perfused rat livers was inhibited by prior infusion of isoproterenol. Similarly, isoproterenol inhibited the biosynthesis of bioactive lipid autacoids such as platelet-activating factor, prostaglandin E2, and thromboxane B2 which was stimulated by immune aggregates. The adrenergic receptor specificity of these effects was determined through the use of specific adrenergic subtype-specific agonists and antagonists to be mediated by beta 2-adrenergic receptors. Indirect evidence for the differential expression of hepatic sinusoidal and parenchymal beta-adrenergic receptors in the male rat during ontogeny suggested that inhibition of immune aggregate-stimulated autacoid biosynthesis, vasoconstriction, and glycogenolysis by isoproterenol occurs at a sinusoidal locus, most likely Kupffer cells. In contrast with the ability of beta 2-adrenergic agonists to inhibit immune aggregate- and platelet-activating factor-stimulated hepatic metabolism, dibutyryl cyclic AMP did not mimic these sinusoidal beta 2-adrenergic effects, despite stimulating hepatic parenchymal cell glycogenolysis as effectively as isoproterenol. These observations suggest a role for cyclic AMP-independent mechanisms in the regulation of heterologous stimulus-response coupling by hepatic sinusoidal beta 2-adrenergic receptors.

Dinoprostone - biosynthesis

Liver - metabolism

Platelet Activating Factor - biosynthesis

Platelet Activating Factor - pharmacology

Vasoconstriction

Rats

Male

Receptors, Adrenergic, beta - physiology

Thromboxane B2 - biosynthesis

Rats, Inbred Strains

Antigen-Antibody Complex - physiology

Liver - blood supply

Animals

Glycogen - metabolism

Liver - drug effects

Isoproterenol - pharmacology

Bucladesine - pharmacology

Details

Title: Subtitle: β2-Adrenergic agonist regulation of immune aggregate- and platelet-activating factor-stimulated hepatic metabolism
Creators: Mark E Steinhelper - Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284-7760
Rory A Fisher
G E Revtyak
Donald J Hanahan
M S Olson
Resource Type: Journal article
Publication Details: The Journal of biological chemistry, Vol.264(19), pp.10976-10981
DOI: 10.1016/S0021-9258(18)60414-4
PMID: 2544577
NLM abbreviation: J Biol Chem
ISSN: 0021-9258
eISSN: 1083-351X
Publisher: United States
Grant note: DK-19473 / NIDDK NIH HHS AM-07358 / NIADDK NIH HHS DK-33538 / NIDDK NIH HHS
Language: English
Date published: 07/05/1989
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040206602771

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