Journal article
γ-interferon inhibits rat granulosa cell differentiation in culture
Biochemical and biophysical research communications, Vol.157(3), pp.891-897
1988
DOI: 10.1016/S0006-291X(88)80958-6
PMID: 3144977
Abstract
A growing body of evidence indicates that factors secreted by cells of the immune system can directly affect a variety of endocrine phenomena. In the present study we examined the direct effects of the cytokine, interferon (IFN), on FSH-stimulated steroidogenesis and LH/hCG receptor induction in rat granulosa cells. We show that γ-IFN, but not α-IFN, inhibits FSH-stimulated progesterone, 20α-hydroxypregn-4-en-3-one and estrogen production as well as gonadotropin-induced LH/hCG receptor formation in a dose-dependent manner. The results suggest that γ-IFN may play a role in the maturation and differentiation of granulosa cells and thus may serve as a regulatory link between the immune and reproductive endocrine systems.
Details
- Title: Subtitle
- γ-interferon inhibits rat granulosa cell differentiation in culture
- Creators
- William C Gorospe - Department of Anatomy and Cell Biology, Medical University of South Carolina, 171 Ashley Ave., Charleston, SC 29425, USATammy Tuchel - Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USABarry G Kasson - Department of Pharmacology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
- Resource Type
- Journal article
- Publication Details
- Biochemical and biophysical research communications, Vol.157(3), pp.891-897
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0006-291X(88)80958-6
- PMID
- 3144977
- ISSN
- 0006-291X
- eISSN
- 1090-2104
- Language
- English
- Date published
- 1988
- Academic Unit
- Neuroscience and Pharmacology
- Record Identifier
- 9984040488702771
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