Journal article
ω-Carboxyl Terminated Cellulose Esters are Effective Crystallization Inhibitors for Challenging Drugs
Journal of pharmaceutical sciences, Vol.114(1), pp.544-553
01/2025
DOI: 10.1016/j.xphs.2024.10.034
PMID: 39481471
Abstract
Polymeric additives are widely used to delay drug crystallization from supersaturated solutions, which is critical for enhancing oral bioavailability by amorphous solid dispersion (ASD). The efficacy of these polymers relies on their capacity to inhibit nucleation and subsequent crystal growth. Drug nucleation is pivotal to crystallization; therefore, effective polymers are essential for suppressing nucleation from supersaturated solutions. We studied the performance of cellulose ω-carboxyalkanoates designed as crystallization inhibitors by measuring their influence on nucleation induction times of poorly soluble drugs celecoxib, posaconazole, and enzalutamide, from supersaturated solutions. In the absence of polymers, crystallization occurred within 5 to 15 minutes for all three drugs. Polymer hydrophobicity strongly influenced effectiveness in crystallization inhibition. Hydrophobic polymers prolonged induction times for up to 8 hours, while hydrophilic polymers were less effective, except for cellulose acetate glutarate (CA1.18-GA1.21; degrees of substitution acetate 1.18, glutarate 1.21). The cellulose ω-carboxyalkanoates had glass transition temperatures well above 100 °C, outstanding for ASD stability requirements. We investigated the impact of these designed polymers on surface tension and found that it only weakly influenced crystallization inhibition. Among the nine crafted cellulose derivatives, water-soluble CA1.18-GA1.21 emerged as a highly promising ASD polymer, preventing crystallization for 2-8 hours for all fast-crystallizing model compounds.
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Details
- Title: Subtitle
- ω-Carboxyl Terminated Cellulose Esters are Effective Crystallization Inhibitors for Challenging Drugs
- Creators
- Stella Petrova - Purdue University West LafayetteChengzhe Gao - Purdue University West LafayetteTze Ning Hiew - Purdue University West LafayetteKevin J. Edgar - Virginia TechLynne S. Taylor - Purdue University West Lafayette
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.114(1), pp.544-553
- DOI
- 10.1016/j.xphs.2024.10.034
- PMID
- 39481471
- NLM abbreviation
- J Pharm Sci
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Publisher
- Elsevier Inc
- Grant note
- National Science Foundation: IIP-1827943 Virginia Tech Department of Chemistry
We thank the National Science Foundation (PFI-RP) for most of the funding support of this work through grant IIP-1827943. We thank the Virginia Tech Department of Chemistry for partial support of this work through a Graduate Student Doctoral Assistantship Award (SP) .
- Language
- English
- Electronic publication date
- 10/29/2024
- Date published
- 01/2025
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984740853802771
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