Letter/Communication
An Alert for Motor Neuron Diseases and Peripheral Neuropathy: Monoclonal Paraproteinemia May Be Missed by Routine Electrophoresis
Archives of neurology (Chicago), Vol.44(3), pp.250-251
03/01/1987
DOI: 10.1001/archneur.1987.00520150006005
PMID: 3030245
Abstract
TO THE EDITOR. —We write to alert neurologists about a problem in laboratory diagnosis. Monoclonal paraproteinemia, or monoclonal gammopathy, a form of plasma cell dyscrasia, seems to be found with inordinate frequency in patients with peripheral neuropathy1-3 and motor neuron diseases, including amyotrophic lateral sclerosis.4 The condition is defined by the identification of a monoclonal immunoglobulin in the serum (M protein).In the United States, electrophoresis on cellulose acetate is commonly used to separate the serum proteins, which are then stained. The gel isQuantitative Analysis of Immunoglobulins Diagnosis IgG, mg/dL (g/L) IgA, mg/dL (g/L) IgM, mg/dL (g/L) Immunofixation Electrophoresis Paraprotein Normal range 700-1700 (7.00-12.00) 70-350 (0.70-3.50) 50-300 (0.50-3.00) Motor neuron disease 652 (6.52) 82 (0.82) 518 (5.18) IgMΚ Neuropathy 1120 (11.20) 285 (2.85) 155 (1.55) IgA λ Motor neuron disease 1050 (10.50) 361 (3.61) 107 (1.07) IgAΚ scanned with a densitometer and the curves are inspected visually;
Details
- Title: Subtitle
- An Alert for Motor Neuron Diseases and Peripheral Neuropathy: Monoclonal Paraproteinemia May Be Missed by Routine Electrophoresis
- Creators
- Steven J ZuckermanMichael A PesceLewis P RowlandW ShermanMichael E ShyN LatovElliott F Osserman
- Resource Type
- Letter/Communication
- Publication Details
- Archives of neurology (Chicago), Vol.44(3), pp.250-251
- DOI
- 10.1001/archneur.1987.00520150006005
- PMID
- 3030245
- NLM abbreviation
- Arch Neurol
- ISSN
- 0003-9942
- eISSN
- 1538-3687
- Publisher
- American Medical Association
- Language
- English
- Date published
- 03/01/1987
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020773502771
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