Letter/Communication
C4 Dense-Deposit Disease
The New England journal of medicine, Vol.370(8), pp.784-786
02/20/2014
DOI: 10.1056/NEJMc1309449
PMID: 24552345
Abstract
To the Editor:
Dense-deposit disease is a complement-mediated disorder characterized by a proliferative glomerulonephritis, bright capillary-wall C3 staining on immunofluorescence microscopy, and large intramembranous osmiophilic dense deposits that markedly thicken the glomerular capillary walls.
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The underlying pathophysiology — fluid-phase dysregulation of the alternative pathway — leads to accumulation of C3 breakdown products in the glomerular basement membrane. C4 is conspicuously absent.
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Proteinuria was detected in a 12-year-old Hispanic girl at a well-child visit. The blood urea nitrogen and serum creatinine levels were normal, urinalysis showed trace blood with a urinary protein-to-creatinine ratio of 1.5, and renal ultrasonography showed normal-size . . .
Details
- Title: Subtitle
- C4 Dense-Deposit Disease
- Creators
- Richard J.H SmithAnne SullivanSanjeev Sethi
- Resource Type
- Letter/Communication
- Publication Details
- The New England journal of medicine, Vol.370(8), pp.784-786
- DOI
- 10.1056/NEJMc1309449
- PMID
- 24552345
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Society
- Language
- English
- Date published
- 02/20/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006487102771
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