Cystic Fibrosis Lung Function Decline after Within-Host Evolution Increases Virulence of Infecting Pseudomonas aeruginosa

Peter Jorth; Samantha Durfey; Amir Rezayat; Jayanthi Garudathri; Anina Ratjen; Benjamin J Staudinger; Matthew C Radey; Alan Genatossio; Sharon McNamara; David A Cook; Moira L Aitken; Ronald L Gibson; Timothy L Yahr; Pradeep K Singh

doi:10.1164/rccm.202007-2735LE

Back

Cystic Fibrosis Lung Function Decline after Within-Host Evolution Increases Virulence of Infecting Pseudomonas aeruginosa

Letter/Communication

Open access

Cystic Fibrosis Lung Function Decline after Within-Host Evolution Increases Virulence of Infecting Pseudomonas aeruginosa

Peter Jorth, Samantha Durfey, Amir Rezayat, Jayanthi Garudathri, Anina Ratjen, Benjamin J Staudinger, Matthew C Radey, Alan Genatossio, Sharon McNamara, David A Cook, …

American journal of respiratory and critical care medicine, Vol.203(5), pp.637-640

03/01/2021

DOI: 10.1164/rccm.202007-2735LE

PMCID: PMC7924579

PMID: 33137262

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7924579View

Published (Version of record) Open Access

Abstract

Bacterial Proteins - genetics

Cystic Fibrosis - complications

Cystic Fibrosis - microbiology

Cystic Fibrosis - physiopathology

Disease Progression

Evolution, Molecular

Humans

Male

Mutation, Missense

Pseudomonas aeruginosa - genetics

Pseudomonas aeruginosa - pathogenicity

Pseudomonas Infections - complications

Pseudomonas Infections - microbiology

Pseudomonas Infections - physiopathology

Repressor Proteins - genetics

Sequence Analysis, DNA

Trans-Activators - genetics

Type III Secretion Systems - genetics

Virulence - genetics

Young Adult

Details

Title: Subtitle: Cystic Fibrosis Lung Function Decline after Within-Host Evolution Increases Virulence of Infecting Pseudomonas aeruginosa
Creators: Peter Jorth - Cedars-Sinai Medical Center
Samantha Durfey - University of Washington
Amir Rezayat - University of Washington
Jayanthi Garudathri - University of Washington
Anina Ratjen - University of Washington
Benjamin J Staudinger - University of Washington
Matthew C Radey - University of Washington
Alan Genatossio - Seattle Children's Hospital
Sharon McNamara - Seattle Children's Hospital
David A Cook - Washington Hospital
Moira L Aitken - University of Washington
Ronald L Gibson - University of Washington
Timothy L Yahr - University of Iowa
Pradeep K Singh - University of Washington
Resource Type: Letter/Communication
Publication Details: American journal of respiratory and critical care medicine, Vol.203(5), pp.637-640
DOI: 10.1164/rccm.202007-2735LE
PMID: 33137262
PMCID: PMC7924579
ISSN: 1073-449X
eISSN: 1535-4970
Grant note: K24 HL102246 / NHLBI NIH HHS R56 AI055042 / NIAID NIH HHS P30 DK089507 / NIDDK NIH HHS R56 HL141098 / NHLBI NIH HHS R01 HL148274 / NHLBI NIH HHS R01 AI055042 / NIAID NIH HHS P30 DK054759 / NIDDK NIH HHS K22 AI127473 / NIAID NIH HHS
Language: English
Date published: 03/01/2021
Academic Unit: Microbiology and Immunology
Record Identifier: 9984297439002771

Metrics

9 Record Views

9 Times Cited - Web of Science

See more details