DLPFC TMS Suppresses High-Frequency Neural Activity in the Human sgACC

Ethan A. Solomon; Umair Hassan; Nicholas T. Trapp; Aaron D. Boes; Corey J. Keller

doi:10.1016/j.brs.2025.11.012

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DLPFC TMS Suppresses High-Frequency Neural Activity in the Human sgACC

Letter/Communication

Open access

DLPFC TMS Suppresses High-Frequency Neural Activity in the Human sgACC

Ethan A. Solomon, Umair Hassan, Nicholas T. Trapp, Aaron D. Boes and Corey J. Keller

Brain stimulation, Vol.19(1), 102985

01/2026

DOI: 10.1016/j.brs.2025.11.012

PMCID: PMC12955852

PMID: 41241258

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Abstract

Highlights •TMS combined with iEEG was used to assess neural responses to stimulation. •DLPFC stimulation caused decreases in high-frequency activity in the sgACC. •High-frequency activity was anticorrelated between the sgACC and DLPFC.•Stimulation increased theta phase coupling between the two regions.

Details

Title: Subtitle: DLPFC TMS Suppresses High-Frequency Neural Activity in the Human sgACC
Creators: Ethan A. Solomon - Stanford University
Umair Hassan - Stanford University
Nicholas T. Trapp - University of Iowa
Aaron D. Boes - University of Iowa
Corey J. Keller - Stanford University
Resource Type: Letter/Communication
Publication Details: Brain stimulation, Vol.19(1), 102985
DOI: 10.1016/j.brs.2025.11.012
PMID: 41241258
PMCID: PMC12955852
NLM abbreviation: Brain Stimul
ISSN: 1935-861X
eISSN: 1876-4754
Publisher: Elsevier Inc
Grant note: NIMH: R01MH132074, 5T32-MH019113, 1K23MH125145 Roy J. Carver Trust: R21MH120441, R01NS114405 Burroughs Wellcome Fund Career Award for Medical Scientists: R01MH126639, R01MH129018 BBRF Young Investigator Grant: 31275 Penningroth Fellowship in Interventional Psychiatry: T32MH019938, 1K99MH139907-01 University of Iowa Human Brain Research Lab: R01DC004290, 1S10OD025025-01
This work was supported by NIMH R01MH132074 (CJK and ADB) ; R21MH120441, R01NS114405 and Roy J. Carver Trust (ADB) ; R01MH126639, R01MH129018, and Burroughs Wellcome Fund Career Award for Medical Scientists (CJK) ; 5T32-MH019113, NIMH 1K23MH125145, BBRF Young Investigator Grant 31275, and the Penningroth Fellowship in Interventional Psychiatry (NTT) ; T32MH019938 and 1K99MH139907-01 (EAS) . This work was also supported by R01DC004290 for the University of Iowa Human Brain Research Lab. This work was conducted, in part, on an MRI instrument funded by 1S10OD025025-01.
Language: English
Electronic publication date: 11/13/2025
Date published: 01/2026
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9985033849102771

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