Preliminary evidence that early reduction in p11 levels in Natural Killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram

P Svenningsson; L Berg; D Matthews; D F Ionescu; E Richards; M Niciu; A Malinger; M Toups; H Manji; M H Trivedi; C A Zarate; P Greengard

doi:10.1038/mp.2014.13

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Preliminary evidence that early reduction in p11 levels in Natural Killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram

Letter/Communication

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Preliminary evidence that early reduction in p11 levels in Natural Killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram

P Svenningsson, L Berg, D Matthews, D F Ionescu, E Richards, M Niciu, A Malinger, M Toups, H Manji, M H Trivedi, …

Molecular psychiatry, Vol.19(9), pp.962-964

09/2014

DOI: 10.1038/mp.2014.13

PMCID: PMC4161667

PMID: 24614495

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Abstract

The prediction of treatment response in many neuropsychiatric disorders would be facilitated by easily accessible biomarkers. Using flow cytometry, we herein demonstrate correlations between early reductions of p11 levels in Natural Killer (NK) cells and monocytes and antidepressant response to citalopram in patients with major depressive disorder (MDD).

p11

serotonin

Annexin II light chain

antidepressant

depression

biomarker

S100A10

Details

Title: Subtitle: Preliminary evidence that early reduction in p11 levels in Natural Killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram
Creators: P Svenningsson - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
L Berg - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
D Matthews - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
D F Ionescu - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
E Richards - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
M Niciu - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
A Malinger - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
M Toups - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
H Manji - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
M H Trivedi - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
C A Zarate - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
P Greengard - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, USA
Resource Type: Letter/Communication
Publication Details: Molecular psychiatry, Vol.19(9), pp.962-964
DOI: 10.1038/mp.2014.13
PMID: 24614495
PMCID: PMC4161667
NLM abbreviation: Mol Psychiatry
ISSN: 1359-4184
eISSN: 1476-5578
Language: English
Date published: 09/2014
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003948002771

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