The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.
Patent
Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor
United States Patent and Trademark Office
09/07/1993
Abstract
Details
- Title: Subtitle
- Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor
- Creators
- Kevin P Campbell (Inventor)C Michael Knudson (Inventor) - University of Iowa, PathologySteven D Kahl (Inventor)Charles F Louis (Inventor)James R Mickelson (Inventor)
- Contributors
- University of Iowa Research Foundation (Iowa City, IA, US) (Assignee)Regents of the University of Minnesota (Minneapolis, MN) (Assignee)
- Resource Type
- Patent
- Publisher
- United States Patent and Trademark Office; United States
- Patent
- US Patent 5,242,801; Published; 07/562,719; 08/06/1990; 435/7.2; 435/24, 436/63, 436/530, 530/387.1
- Number of pages
- 12 pages
- Language
- English
- Date published
- 09/07/1993
- Academic Unit
- Iowa Neuroscience Institute; UI Research Foundation
- Record Identifier
- 9983761986002771
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