Immunomodulatory oligonucleotides and methods of use therefor

Robert Ashman; Petar Lenert

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Immunomodulatory oligonucleotides and methods of use therefor

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Immunomodulatory oligonucleotides and methods of use therefor

Robert Ashman and Petar Lenert

United States Patent and Trademark Office

02/01/2011

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Abstract

The present invention is drawn a new class of oligodeoxynucleotides (ODNs) that inhibit ODN-activation of Toll-like receptor (TLR)9. Particular 4-5 base extensions at the 5′ and of the previously described core inhibitory ODN sequence enhances their inhibitory activity against human cells expressing human TLR9. Methods of use also are provided.

Details

Title: Subtitle: Immunomodulatory oligonucleotides and methods of use therefor
Creators: Robert Ashman (Inventor)
Petar Lenert (Inventor)
Contributors: University of Iowa Research Foundation (Iowa City, IA, US) (Assignee)
Resource Type: Patent
Publisher: United States Patent and Trademark Office; United States
Patent: US Patent 7,879,812; United States Patent and Trademark Office (United States, Alexandria) - USPTO; Published; 12/185,418; 08/04/2008
Number of pages: 21 pages
Language: English
Date published: 02/01/2011
Academic Unit: Microbiology and Immunology; Internal Medicine; Immunology; UI Research Foundation
Record Identifier: 9983761977402771

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