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Immunostimulatory nucleic acid molecules
Patent   Open access

Immunostimulatory nucleic acid molecules

Arthur M Krieg and Joel N Kline
United States Patent and Trademark Office
04/28/2009
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PDM V1.0 Open Access

Abstract

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful a synthetic adjuvant.

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