Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer

Thomas S Griffith; Timothy Ratliff

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Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer

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Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer

Thomas S Griffith and Timothy Ratliff

United States Patent and Trademark Office

05/31/2005

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Abstract

The present invention is directed to methods for inhibiting tumor cell growth, causing tumor regression or eliminating tumor cells in a mammal afflicted with a tumor by administering to a TRAIL-sensitive cell a vector having a DNA expression cassette containing a promoter and a DNA sequence encoding TRAIL, wherein the expression of TRAIL results in tumor inhibition, regression or elimination.

Details

Title: Subtitle: Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer
Creators: Thomas S Griffith (Inventor)
Timothy Ratliff (Inventor)
Contributors: University of Iowa Research Foundation (Iowa City, IA, US) (Assignee)
Resource Type: Patent
Publisher: United States Patent and Trademark Office; United States
Patent: US Patent 6,900,185; United States Patent and Trademark Office (United States, Alexandria) - USPTO; Published; 09/547,742; 04/12/2000
Number of pages: 24 pages
Language: English
Date published: 05/31/2005
Academic Unit: UI Research Foundation; Urology
Record Identifier: 9983762072402771

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