The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
Patent
Methods for blocking the expression of specifically targeted genes
United States Patent and Trademark Office
02/13/1996
Abstract
Details
- Title: Subtitle
- Methods for blocking the expression of specifically targeted genes
- Creators
- Joseph A Walder (Inventor)Roxanne Y Walder (Inventor)Paul S Eder (Inventor)John M Dagle (Inventor)
- Contributors
- University of Iowa Research Foundation (Iowa City, IA, US) (Assignee)
- Resource Type
- Patent
- Publisher
- United States Patent and Trademark Office; United States
- Patent
- US Patent 5,491,133; United States Patent and Trademark Office (United States, Alexandria) - USPTO; Published; 07/672,088; 03/19/1991
- Number of pages
- 14 pages
- Language
- English
- Date published
- 02/13/1996
- Academic Unit
- UI Research Foundation; Neonatology
- Record Identifier
- 9983761989002771
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