The use of oligodeoxynucleotides modified at the 3'-terminal internucleotide link as therapeutic agents by a method of hybridizing the modified oligonucleotide to a complementary sequence within a targeted mRNA and cleaving the mRNA within the RNA-DNA helix by the enzyme RNaseH to block the expression of the corresponding gene.
Patent
Methods for decreasing the expression of specifically targeted genes
United States Patent and Trademark Office
10/05/1999
Abstract
Details
- Title: Subtitle
- Methods for decreasing the expression of specifically targeted genes
- Creators
- Joseph A Walder (Inventor)Roxanne Y Walder (Inventor)Paul S Eder (Inventor)John M Dagle (Inventor)
- Contributors
- University of Iowa Research Foundation (Iowa City, IA, US) (Assignee)
- Resource Type
- Patent
- Publisher
- United States Patent and Trademark Office; United States
- Patent
- US Patent 5,962,425; United States Patent and Trademark Office (United States, Alexandria) - USPTO; Published; 08/460,704; 06/02/1995
- Number of pages
- 16 pages
- Language
- English
- Date published
- 10/05/1999
- Academic Unit
- UI Research Foundation; Epidemiology; Stead Family Department of Pediatrics; Biochemistry and Molecular Biology; Neonatology
- Record Identifier
- 9983761981402771
Metrics
14 File views/ downloads
24 Record Views