Methods of treating cancer using immunostimulatory oligonucleotides

Arthur M Krieg; Alfred D Steinberg; Dennis Klinman

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Methods of treating cancer using immunostimulatory oligonucleotides

Patent

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Methods of treating cancer using immunostimulatory oligonucleotides

Arthur M Krieg, Alfred D Steinberg and Dennis Klinman

United States Patent and Trademark Office

08/30/2011

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Abstract

Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.

Details

Title: Subtitle: Methods of treating cancer using immunostimulatory oligonucleotides
Creators: Arthur M Krieg (Inventor)
Alfred D Steinberg (Inventor)
Dennis Klinman (Inventor)
Contributors: University of Iowa Research Foundation (Iowa City, IA, US) (Assignee)
The United States of America, as represented by the Department of Health and Human Services (Washington, DC, US) (Assignee)
Coley Pharmaceutical Group, Inc. (New York, NY, US) (Assignee)
Resource Type: Patent
Publisher: United States Patent and Trademark Office; United States
Patent: US Patent 8,008,266; United States Patent and Trademark Office (United States, Alexandria) - USPTO; Published; 10/719,493; 11/21/2003
Number of pages: 74 pages
Language: English
Date published: 08/30/2011
Academic Unit: UI Research Foundation
Record Identifier: 9983762095902771

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