Activity-induced gene expression in the human brain

Snehajyoti Chatterjee; Yann Vanrobaeys; Shane A. Heiney; Ariane E. Rhone; Kirill V. Nourski; Lucy Langmack; Utsav Mukherjee; Christopher K. Kovach; Zsuzsanna Kocsis; Yukiko Kikuchi; Christopher I. Petkov; Marco M. Hefti; Ethan Bahl; Jacob J Michaelson; Hiroto Kawasaki; Hiroyuki Oya; Matthew A. Howard; Thomas Nickl-Jockschat; Li-Chun Lin; Ted Abel

doi:10.1101/2023.09.21.558812

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Activity-induced gene expression in the human brain

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Open access

Activity-induced gene expression in the human brain

Snehajyoti Chatterjee, Yann Vanrobaeys, Shane A. Heiney, Ariane E. Rhone, Kirill V. Nourski, Lucy Langmack, Utsav Mukherjee, Christopher K. Kovach, Zsuzsanna Kocsis, Yukiko Kikuchi, …

bioRxiv

Cold Spring Harbor Laboratory

09/21/2023

DOI: 10.1101/2023.09.21.558812

PMCID: PMC10542502

PMID: 37790527

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https://doi.org/10.1101/2023.09.21.558812View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Genes related to transcriptional regulation and microglia-specific cytokine activity displayed the greatest induction pattern, revealing a precise molecular signature of neuronal activation in the human brain.

Details

Title: Subtitle: Activity-induced gene expression in the human brain
Creators: Snehajyoti Chatterjee - University of Iowa
Yann Vanrobaeys - University of Iowa
Shane A. Heiney - University of Iowa
Ariane E. Rhone - University of Iowa
Kirill V. Nourski - University of Iowa
Lucy Langmack - University of Iowa
Utsav Mukherjee - University of Iowa
Christopher K. Kovach - University of Iowa
Zsuzsanna Kocsis - University of Iowa
Yukiko Kikuchi - Newcastle University
Christopher I. Petkov - University of Iowa
Marco M. Hefti - University of Iowa
Ethan Bahl - University of Iowa
Jacob J Michaelson - University of Iowa
Hiroto Kawasaki - University of Iowa
Hiroyuki Oya - University of Iowa
Matthew A. Howard - University of Iowa
Thomas Nickl-Jockschat
Li-Chun Lin - University of Iowa
Ted Abel - University of Iowa
Resource Type: Preprint
Publication Details: bioRxiv
DOI: 10.1101/2023.09.21.558812
PMID: 37790527
PMCID: PMC10542502
Publisher: Cold Spring Harbor Laboratory
Language: English
Date posted: 09/21/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Communication Sciences and Disorders; Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Pathology; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology; Neurosurgery; Otolaryngology
Record Identifier: 9984473304002771

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