Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Vishal Midya; Kiran Nagdeo; Jamil Lane; Libni Torres-Olascoaga; Gabriela Martínez; Megan Horton; Chris Gennings; Martha Téllez-Rojo; Robert Wright; Manish Arora; Shoshannah Eggers

doi:10.21203/rs.3.rs-3922286/v1

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Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

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Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood

Vishal Midya, Kiran Nagdeo, Jamil Lane, Libni Torres-Olascoaga, Gabriela Martínez, Megan Horton, Chris Gennings, Martha Téllez-Rojo, Robert Wright, Manish Arora, …

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02/14/2024

DOI: 10.21203/rs.3.rs-3922286/v1

PMCID: PMC10896378

PMID: 38410473

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https://doi.org/10.21203/rs.3.rs-3922286/v1View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Emerging research suggests that exposures to metals during pregnancy and gut microbiome (GM) disruptions are associated with depressive disorders in childhood. , a GM bacteria, has been studied for its potential antidepressant effects. However, its role in the influence of prenatal metal exposures on depressive symptoms during childhood is unknown. Leveraging a well-characterized pediatric longitudinal birth cohort and its microbiome substudy (n=112) and using a state-of-the-art machine-learning model, we investigated whether the presence of in GM of 9-11-year-olds modifies the associations between exposure to a specific group of metals (or metal-clique) during pregnancy and concurrent childhood depressive symptoms. Among children with no , a metal-clique of Zinc-Chromium-Cobalt was strongly associated with increased depression score ( <0.0001), whereas, for children with , this same metal-clique was weakly associated with decreased depression score( <0.4). Our analysis provides the first exploratory evidence hypothesizing as a probiotic intervention attenuating the effect of prenatal metal-exposures-associated depressive disorders in late childhood.

Details

Title: Subtitle: Akkermansia muciniphila modifies the association between metal exposure during pregnancy and depressive symptoms in late childhood
Creators: Vishal Midya - Icahn School of Medicine at Mount Sinai
Kiran Nagdeo - Icahn School of Medicine at Mount Sinai
Jamil Lane - Icahn School of Medicine at Mount Sinai
Libni Torres-Olascoaga - National Institute of Public Health
Gabriela Martínez - National Institute of Public Health
Megan Horton - Icahn School of Medicine at Mount Sinai
Chris Gennings - Icahn School of Medicine at Mount Sinai
Martha Téllez-Rojo
Robert Wright - Icahn School of Medicine at Mount Sinai
Manish Arora - Icahn School of Medicine at Mount Sinai
Shoshannah Eggers - University of Iowa
Resource Type: Preprint
Publication Details: Research square
DOI: 10.21203/rs.3.rs-3922286/v1
PMID: 38410473
PMCID: PMC10896378
Language: English
Date posted: 02/14/2024
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9984561460202771

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