Brain Charts for the Rhesus Macaque Lifespan

S. Alldritt; T.D. Griffiths; J.S.B. Ramirez; C.I. Petkov; R. Vos de Wael; R. Bethlehem; J. Seidlitz; Z. Wang; K. Nenning; N.B. Esper; J. Smallwood; A.R. Franco; K. Byeon; A. Alexander-Bloch; D.G. Amaral; C. Amiez; F. Balezeau; M.G. Baxter; G. Becker; J. Bennett; O. Berkner; E.L.A. Blezer; A.M. Brambrink; T. Brochier; B. Butler; L.J. Campos; E. Canet-Soulas; L. Chalet; A. Chen; J. Cléry; C. Constantinidis; D.J. Cook; S. Dehaene; L. Dorfschmidt; C.M. Drzewiecki; J.W. Erdman; S. Everling; A. Falchier; L. Fleysher; A. Fox; W. Freiwald; M. Froesel; S. Froudist-Walsh; J. Fudge; T. Funck; M. Gacoin; D.J. Gale; J. Gallivan; C.M. Garin; C. Guedj; F. Hadj-Bouziane; S.B. Hamed; N. Harel; R. Hartig; B. Hiba; B.R. Howell; B. Jarraya; B. Jung; N. Kalin; S. Kastner; J. Karpf; C. Klink; Z.A. Kovacs-Balint; C. Kroenke; M.J. Kuchan; S.C. Kwok; K.N. Lala; D.A. Leopold; G. Li; P. Lindenfors; G. Linn; R.B. Mars; K. Masiello; R.S. Menon; A. Messinger; M. Meunier; K. Mok; J.H. Morrison; J. Nacef; J. Nagy; V. Neudecker; M. Neuringer; M.P. Noonan; M. Ortiz-Rios; J.F. Perez-Zoghbi; M. Pinsk; C. Poirier; E. Procyk; R. Rajimehr; S.M. Reader; D.A. Rudko; M.F.S. Rushworth; B.E. Russ; J. Sallet; M.M. Sanchez; M.C. Schmid; C.M. Schwiedrzik; J.A. Scott; J. Sein; K.K. Sharma; A. Shmuel; M. Styner; E.L. Sullivan; A. Thiele; O.S. Todorov; D. Tsao; A. Tusche; R. Vlasova; L. Wang; J. Wang; A.R. Weiss; C.R.E. Wilson; E. Yacoub; W. Zarco; Y. Zhou; J. Zhu; D. Margulies; D. Fair; C. Schroeder; M. Milham; T. Xu

doi:10.1101/2024.08.28.610193

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Brain Charts for the Rhesus Macaque Lifespan

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Brain Charts for the Rhesus Macaque Lifespan

S. Alldritt, T.D. Griffiths, J.S.B. Ramirez, C.I. Petkov, R. Vos de Wael, R. Bethlehem, J. Seidlitz, Z. Wang, K. Nenning, N.B. Esper, …

bioRxiv

Cold Spring Harbor Laboratory

08/30/2024

DOI: 10.1101/2024.08.28.610193

PMCID: PMC11383706

PMID: 39257737

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https://doi.org/10.1101/2024.08.28.610193View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Recent efforts to chart human brain growth across the lifespan using large-scale MRI data have provided reference standards for human brain development. However, similar models for nonhuman primate (NHP) growth are lacking. The rhesus macaque, a widely used NHP in translational neuroscience due to its similarities in brain anatomy, phylogenetics, cognitive, and social behaviors to humans, serves as an ideal NHP model. This study aimed to create normative growth charts for brain structure across the macaque lifespan, enhancing our understanding of neurodevelopment and aging, and facilitating cross-species translational research. Leveraging data from the PRIMatE Data Exchange (PRIME-DE) and other sources, we aggregated 1,522 MRI scans from 1,024 rhesus macaques. We mapped non-linear developmental trajectories for global and regional brain structural changes in volume, cortical thickness, and surface area over the lifespan. Our findings provided normative charts with centile scores for macaque brain structures and revealed key developmental milestones from prenatal stages to aging, highlighting both species-specific and comparable brain maturation patterns between macaques and humans. The charts offer a valuable resource for future NHP studies, particularly those with small sample sizes. Furthermore, the interactive open resource ( https://interspeciesmap.childmind.org ) supports cross-species comparisons to advance translational neuroscience research.

Details

Title: Subtitle: Brain Charts for the Rhesus Macaque Lifespan
Creators: S. Alldritt - Child Mind Institute
T.D. Griffiths - Newcastle University
J.S.B. Ramirez - Child Mind Institute
C.I. Petkov - University of Iowa
R. Vos de Wael
R. Bethlehem
J. Seidlitz - University of Pennsylvania
Z. Wang
K. Nenning - Nathan Kline Institute for Psychiatric Research
N.B. Esper - Child Mind Institute
J. Smallwood - Queens University
A.R. Franco - Child Mind Institute
K. Byeon - Child Mind Institute
A. Alexander-Bloch
D.G. Amaral - University of California, Davis
C. Amiez - Institut Cellule Souche et Cerveau
F. Balezeau - Newcastle University
M.G. Baxter - Wake Forest University
G. Becker - Université Claude Bernard Lyon 1
J. Bennett - University of California, Davis
O. Berkner - Nathan Kline Institute for Psychiatric Research
E.L.A. Blezer - University Medical Center Utrecht
A.M. Brambrink - Columbia University
T. Brochier - Aix-Marseille Université
B. Butler - Nathan Kline Institute for Psychiatric Research
L.J. Campos - University of California, Davis
E. Canet-Soulas
L. Chalet - Université Claude Bernard Lyon 1
A. Chen - East China Normal University
J. Cléry - McGill University
C. Constantinidis - Vanderbilt University
D.J. Cook - Queens University
S. Dehaene
L. Dorfschmidt - University of Pennsylvania
C.M. Drzewiecki - University of California, Davis
J.W. Erdman - University of Illinois Urbana-Champaign
S. Everling - Western University
A. Falchier - Nathan Kline Institute for Psychiatric Research
L. Fleysher - Icahn School of Medicine at Mount Sinai
A. Fox - University of California, Davis
W. Freiwald - Rockefeller University
M. Froesel - Institut des Sciences Cognitives
S. Froudist-Walsh
J. Fudge - University of Rochester
T. Funck - Child Mind Institute
M. Gacoin - Institut des Sciences Cognitives
D.J. Gale - Queens University
J. Gallivan - Queens University
C.M. Garin - Vanderbilt University
C. Guedj - Centre de Recherche en Neurosciences de Lyon
F. Hadj-Bouziane
S.B. Hamed
N. Harel - University of Minnesota System
R. Hartig - Nathan Kline Institute for Psychiatric Research
B. Hiba - Institut des Sciences Cognitives
B.R. Howell - Biomedical Research Institute
B. Jarraya - NeuroSpine Institute
B. Jung - University of Pennsylvania
N. Kalin - University of Wisconsin–Madison
S. Kastner - Princeton University
J. Karpf - Oregon National Primate Research Center
C. Klink
Z.A. Kovacs-Balint - Emory and Henry College
C. Kroenke - Oregon National Primate Research Center
M.J. Kuchan - Abbott (United Kingdom)
S.C. Kwok - Duke Kunshan University
K.N. Lala
D.A. Leopold
G. Li
P. Lindenfors - Centre for Palaeogenetics
G. Linn - Nathan Kline Institute for Psychiatric Research
R.B. Mars - University of Oxford
K. Masiello - Nathan Kline Institute for Psychiatric Research
R.S. Menon - Western University
A. Messinger
M. Meunier - Centre de Recherche en Neurosciences de Lyon
K. Mok - McGill University
J.H. Morrison
J. Nacef - Newcastle University
J. Nagy - Icahn School of Medicine at Mount Sinai
V. Neudecker - Columbia University
M. Neuringer - Oregon Health & Science University
M.P. Noonan - University of York
M. Ortiz-Rios - German Primate Center
J.F. Perez-Zoghbi
M. Pinsk - Princeton University
C. Poirier - Newcastle University
E. Procyk - Institut Cellule Souche et Cerveau
R. Rajimehr - McGovern Institute for Brain Research
S.M. Reader - McGill University
D.A. Rudko - McGill University
M.F.S. Rushworth - University of Oxford
B.E. Russ - Nathan Kline Institute for Psychiatric Research
J. Sallet - University of Oxford
M.M. Sanchez - Emory and Henry College
M.C. Schmid - University of Fribourg
C.M. Schwiedrzik - European Neuroscience Institute Göttingen
J.A. Scott - Santa Clara University
J. Sein - Aix-Marseille Université
K.K. Sharma - University of Rochester
A. Shmuel - McGill University
M. Styner - University of North Carolina at Chapel Hill
E.L. Sullivan - Oregon Health & Science University
A. Thiele - Newcastle University
O.S. Todorov - Utrecht University
D. Tsao - California Institute of Technology
A. Tusche - Queens University
R. Vlasova - University of North Carolina at Chapel Hill
L. Wang - East China Normal University
J. Wang - Kunming University of Science and Technology
A.R. Weiss
C.R.E. Wilson
E. Yacoub - University of Minnesota System
W. Zarco - Rockefeller University
Y. Zhou - Allen Institute for Brain Science
J. Zhu - Vanderbilt University
D. Margulies
D. Fair - University of Minnesota System
C. Schroeder - Nathan Kline Institute for Psychiatric Research
M. Milham - Child Mind Institute
T. Xu - Child Mind Institute
Resource Type: Preprint
Publication Details: bioRxiv
DOI: 10.1101/2024.08.28.610193
PMID: 39257737
PMCID: PMC11383706
NLM abbreviation: bioRxiv
eISSN: 2692-8205
Publisher: Cold Spring Harbor Laboratory
Language: English
Date posted: 08/30/2024
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984702956402771

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