DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC

Ethan A. Solomon; Umair Hassan; Nicholas T. Trapp; Aaron D. Boes; Corey J. Keller

doi:10.1101/2025.03.26.645556

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DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC

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DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC

Ethan A. Solomon, Umair Hassan, Nicholas T. Trapp, Aaron D. Boes and Corey J. Keller

bioRxiv

Cold Spring Harbor Laboratory, 1.1

04/01/2025

DOI: 10.1101/2025.03.26.645556

PMCID: PMC11996418

PMID: 40235994

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https://doi.org/10.1101/2025.03.26.645556View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate cortex (sgACC). However, we have a limited understanding of how TMS influences neural activity in the sgACC, owing to its deep location within the brain. To better understand the mechanism of antidepressant response to TMS, we recruited two neurosurgical patients with indwelling electrodes and delivered TMS pulses to the DLPFC while simultaneously recording local field potentials from the sgACC. Spectral analysis revealed a decrease in high-frequency activity (HFA; 70-180 Hz) after each stimulation pulse, which was especially pronounced in the sgACC relative to other regions. TMS-evoked HFA power was generally anticorrelated between the DLPFC and sgACC, even while low-frequency phase locking between the two regions was enhanced. Together, these findings support the notion that TMS to the DLPFC can suppress neural firing in the sgACC, suggesting a possible mechanism by which this treatment regulates mood.

Neuroscience

Details

Title: Subtitle: DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC
Creators: Ethan A. Solomon - Stanford Medicine
Umair Hassan - Stanford Medicine
Nicholas T. Trapp - Department of Psychiatry, Carver College of Medicine, University of Iowa
Aaron D. Boes - Department of Pediatrics, Carver College of Medicine, University of Iowa
Corey J. Keller - Stanford University
Resource Type: Preprint
Publication Details: bioRxiv
Edition: 1.1
DOI: 10.1101/2025.03.26.645556
PMID: 40235994
PMCID: PMC11996418
NLM abbreviation: bioRxiv
ISSN: 2692-8205
eISSN: 2692-8205
Publisher: Cold Spring Harbor Laboratory
Number of pages: 17
Language: English
Date posted: 04/01/2025
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984811223902771

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