Genetic Modifiers of Prenatal Brain Injury After Zika Virus Infection: A Scoping Review

Fernanda J P Marques; Janet Ruan; Rozel B Razal; Marcio Leyser; Youssef A Kousa

doi:10.1101/2025.01.02.25319896

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Genetic Modifiers of Prenatal Brain Injury After Zika Virus Infection: A Scoping Review

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Genetic Modifiers of Prenatal Brain Injury After Zika Virus Infection: A Scoping Review

Fernanda J P Marques, Janet Ruan, Rozel B Razal, Marcio Leyser and Youssef A Kousa

medRxiv

Cold Spring Harbor Laboratory Press, 1.1

01/02/2025

DOI: 10.1101/2025.01.02.25319896

PMCID: PMC11722481

PMID: 39802783

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https://doi.org/10.1101/2025.01.02.25319896View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Introduction: The severity of virally induced prenatal brain injury, even among dizygotic twins, varies according to individual and maternal risk and protective factors, including genomics. Objective: This scoping review aims to analyze data on genetic susceptibility to neurological outcomes in children exposed in utero to Zika virus. Methods: We followed JBI methodology for this scoping review. A search in PubMed, Scopus, CINAHL, Web of Science, Academic Search Ultimate, Agricola, Health Source: Nursing/Academic Edition, and Psychology and Behavioral Sciences Collection was conducted. Three reviewers independently screened studies using the Rayyan platform. Studies on gene mutations impacting brain injury after Zika virus infection were included.Results: Thirteen articles identifying candidate genes related to brain injury were reviewed. Twenty-three genes were implicated in modulating susceptibility to prenatal brain injury, including six maternal and 17 infant genes. Conclusion: Maternal and fetal genetic factors likely contribute susceptibility to virally induced prenatal brain injury. Analyzing polygenic risk could aid in future screening programs to identify individuals at risk. This information may eventually be integrated into clinical data, helping healthcare providers, families, and patients understand how to personalize care for better outcomes.

Genetic and Genomic Medicine

Details

Title: Subtitle: Genetic Modifiers of Prenatal Brain Injury After Zika Virus Infection: A Scoping Review
Creators: Fernanda J P Marques - Sarah Network of Rehabilitation Hospitals
Janet Ruan - Children's National
Rozel B Razal - Children's National
Marcio Leyser - University of Iowa
Youssef A Kousa - Children's National
Resource Type: Preprint
Publication Details: medRxiv
Edition: 1.1
DOI: 10.1101/2025.01.02.25319896
PMID: 39802783
PMCID: PMC11722481
Publisher: Cold Spring Harbor Laboratory Press
Language: English
Date posted: 01/02/2025
Academic Unit: Stead Family Department of Pediatrics; Developmental and Behavioral Pediatrics
Record Identifier: 9984774251002771

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