Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection

Jax Skye; Joel Bruss; Sebastian Toescu; Kristian Aquilina; Gino Bardi Lola; Aaron D Boes

doi:10.1101/2023.01.12.23284375

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Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection

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Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection

Jax Skye, Joel Bruss, Sebastian Toescu, Kristian Aquilina, Gino Bardi Lola and Aaron D Boes

medRxiv : the preprint server for health sciences

01/14/2023

DOI: 10.1101/2023.01.12.23284375

PMCID: PMC9882444

PMID: 36711770

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https://doi.org/10.1101/2023.01.12.23284375View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Approximately 25% of pediatric patients who undergo cerebellar tumor resection develop cerebellar mutism syndrome (CMS). Our group recently showed that damage to the cerebellar outflow pathway is associated with increased risk of CMS. Here, we tested whether these findings replicate in an independent cohort. We evaluated the relationship between lesion location and the development of CMS in an observational study of 56 pediatric patients who underwent cerebellar tumor resection. We hypothesized that individuals that developed CMS after surgery (CMS+), relative to those that did not (CMS-) would have lesions that preferentially intersected with: 1) the cerebellar outflow pathway, and 2) a previously generated 'lesion-symptom map' of CMS. Analyses were conducted in accordance with pre-registered hypotheses and analytic methods ( https://osf.io/r8yjv/ ). We found supporting evidence for both hypotheses. Compared with CMS-patients, CMS+ patients (n=10) had lesions with greater overlap with the cerebellar outflow pathway (Cohen's d=.73, p=.05), and the CMS lesion-symptom map (Cohen's d=1.1, p=.004). These results strengthen the association of lesion location with risk of developing CMS and demonstrate generalizability across cohorts. These findings may help to inform the optimal surgical approach to pediatric cerebellar tumors.

Details

Title: Subtitle: Investigating lesion location in relation to cerebellar mutism following pediatric tumor resection
Creators: Jax Skye
Joel Bruss
Sebastian Toescu
Kristian Aquilina
Gino Bardi Lola
Aaron D Boes
Resource Type: Preprint
Publication Details: medRxiv : the preprint server for health sciences
DOI: 10.1101/2023.01.12.23284375
PMID: 36711770
PMCID: PMC9882444
Language: English
Date posted: 01/14/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
Record Identifier: 9984363740702771

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