Preprint
Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study
Research Square
American Journal Experts
09/28/2023
DOI: 10.21203/rs.3.rs-3179362/v1
PMCID: PMC10571603
PMID: 37841855
Abstract
Formal thought disorder (FTD) is a key clinical factor in schizophrenia, but the neurobiological underpinnings remain unclear. In particular, relationship between FTD symptom dimensions and patterns of regional brain volume deficiencies in schizophrenia remain to be established in large cohorts. Even less is known about the cellular basis of FTD. Our study addresses these major obstacles based on a large multi-site cohort through the ENIGMA Schizophrenia Working Group (752 individuals with schizophrenia and 1256 controls), to unravel the neuroanatomy of positive, negative and total FTD in schizophrenia and their cellular bases. We used virtual histology tools to relate brain structural changes associated with FTD to cellular distributions in cortical regions. We identified distinct neural networks for positive and negative FTD. Both networks encompassed fronto-occipito-amygdalar brain regions, but negative FTD showed a relative sparing of orbitofrontal cortical thickness, while positive FTD also affected lateral temporal cortices. Virtual histology identified distinct transcriptomic fingerprints associated for both symptom dimensions. Negative FTD was linked to neuronal and astrocyte fingerprints, while positive FTD was also linked to microglial cell types. These findings relate different dimensions of FTD to distinct brain structural changes and their cellular underpinnings, improve our mechanistic understanding of these key psychotic symptoms.
Details
- Title: Subtitle
- Neural Correlates of Positive and Negative Formal Thought Disorder in Individuals with Schizophrenia: An ENIGMA Schizophrenia Working Group Study
- Creators
- Thomas Nickl-JockschatRachel Sharkey - University of IowaChelsea Bacon - University of IowaZeru Peterson - University of IowaKelly Rootes-MurdyRaymond SalvadorEdith PomarolAndriana KarukPhilipp Homan - University of ZurichEllen Ji - University of ZurichWolfgang Omlor - University of ZurichStephanie HomanFoivos Georgiadis - University of ZurichStefan KaiserMatthias KirschnerStefan EhrlichUdo Dannlowski - University of MünsterDominik GrotegerdJanik Goltermann - University of MünsterSusanne Meinert - University of MünsterTilo KircherFrederike SteinKatharina BroschAxel Krug - University of BonnIgor Nenadic - Philipps University of MarburgKang SimFabrizio Piras - Fondazione Santa LuciaNerisa Banaj - Fondazione Santa LuciaScott Sponheim - Minneapolis VA Health Care SystemCaroline Demro - Minneapolis VA Health Care SystemIan Ramsay - University of Minnesota SystemMargaret KingYann Quidé - UNSW SydneyMelissa Green - UNSW SydneyDana NguyenAdrian Preda - UC Irvine HealthVince Calhoun - Georgia Institute of TechnologyJessica Turner - Georgia State UniversityTheo van ErpGianfranco Spalletta
- Resource Type
- Preprint
- Publication Details
- Research Square
- DOI
- 10.21203/rs.3.rs-3179362/v1
- PMID
- 37841855
- PMCID
- PMC10571603
- Publisher
- American Journal Experts
- Language
- English
- Date posted
- 09/28/2023
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984482457502771
Metrics
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