Preprint
Non-right handedness is associated with language and reading impairments
PsyArXiv
03/07/2022
Abstract
Worldwide, the majority of people prefer using the right hand for most motor tasks. Because of the link between handedness and language hemispheric dominance, handedness has been studied for association with language-related disorders. No clear pattern has emerged from these studies, and inconsistencies have been attributed to small sample sizes, publication bias, and heterogeneous criteria for the definition of handedness and disorders. Here, we assessed the frequency of non-right handedness (NRH) in 10 distinct cohorts not analysed before in this context. We identified N = 2,528 cases with reading and/or language impairment and N = 3,050 unique controls on the basis of a priori defined criteria. Overall, NRH was more frequent and more variable in the cases (8-24%) than in the controls (8-16%). Meta-analysis in the eight cohorts that met the inclusion criteria showed an increase of NRH in individuals with language/reading impairment compared to controls (OR = 1.21, CI = 1.03 - 1.44, p = 0.025). No moderator effects were detected for type of cohort (epidemiological versus clinical) and type of impairment (language versus reading). Our results support an association between NRH and reading and language impairments which could result from shared biological pathways underlying brain lateralization, handedness, and cognitive functions
Details
- Title: Subtitle
- Non-right handedness is associated with language and reading impairments
- Creators
- Filippo AbbondanzaPhilip S DaleCarol A WangEmma Hayiou-ThomasUmar ToseebTanner S KoomarKaren G WiggYu FengKaitlyn M PriceElizabeth KerrSharon L GugerMaureen W LovettLisa J StrugElsje van BergenConor V DolanJ Bruce TomblinKristina MollGerd Schulte-KörneNina NeuhoffAndreas WarnkeSimon E FisherCathy L BarrJacob J MichaelsonDorret I BoomsmaMargaret Jean SnowlingCharles HulmeAndrew J.O WhitehouseCraig E PennellDianne F NewburyJohn SteinJoel B TalcottDorothy V. M BishopSilvia Paracchini
- Resource Type
- Preprint
- Publication Details
- PsyArXiv
- Language
- English
- Date posted
- 03/07/2022
- Academic Unit
- Psychiatry; Communication Sciences and Disorders; Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute
- Record Identifier
- 9984353647102771
Metrics
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