Optimal Needle Placement for Prostate Rotating-Shield Brachytherapy (RSBT)

Jirong Yi; Quentin E Adams; Karolyn M Hopfensperger; Ryan T Flynn; Yusung Kim; John M Buatti; Weiyu Xu; Xiaodong Wu

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Optimal Needle Placement for Prostate Rotating-Shield Brachytherapy (RSBT)

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Optimal Needle Placement for Prostate Rotating-Shield Brachytherapy (RSBT)

Jirong Yi, Quentin E Adams, Karolyn M Hopfensperger, Ryan T Flynn, Yusung Kim, John M Buatti, Weiyu Xu and Xiaodong Wu

ArXiv.org

10/15/2021

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https://arxiv.org/abs/2110.07841View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Purpose: To present an efficient NEEdle Position Optimization (NEEPO) algorithm for prostate rotating shield brachytherapy (RSBT). With RSBT, the increased flexibility beyond conventional high-dose-rate brachytherapy (HDR-BT) due to the partially shielded radiation source has been shown by Adams et al. in 2020 to enable improved urethra sparing (23.1%), enhanced dose escalation (29.9%), or both, with 20 needles without NEEPO-optimized positions. Within this regime of improved dosimetry, we propose in this work that the benefits of RSBT can be maintained while also reducing the number of needles needed for the delivery. The goal of NEEPO is to provide the capability to further increase the dosimetric benefit of RSBT and to minimize the number of needles needed to satisfy a dosimetric goal. Methods: The NEEPO algorithm generates a needle pool for a given patient and then iteratively constructs a subset of needles from the pool based on relative needle importance as determined by total dwell times within needles. The NEEPO algorithm is based on a convex optimization formulation using a quadratic dosimetric penalty function, dwell time regularization by total variation, and a block sparsity regularization term to enable iterative removal of low-importance needles. RSBT treatment plans for 26 patients were generated using single fraction prescriptions with both dose escalation and urethra sparing goals, and compared to baseline HDR-BT treatment plans.

Physics - Medical Physics

Details

Title: Subtitle: Optimal Needle Placement for Prostate Rotating-Shield Brachytherapy (RSBT)
Creators: Jirong Yi
Quentin E Adams
Karolyn M Hopfensperger
Ryan T Flynn
Yusung Kim
John M Buatti
Weiyu Xu
Xiaodong Wu
Resource Type: Preprint
Publication Details: ArXiv.org
ISSN: 2331-8422
Number of pages: 13 pages
Language: English
Date posted: 10/15/2021
Academic Unit: Electrical and Computer Engineering; Radiation Oncology
Record Identifier: 9984197923302771

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