Preprint
Reproducibility of Retinal Thickness Measurements across Spectral-Domain Optical Coherence Tomography Devices using Iowa Reference Algorithm
ArXiv.org
12/19/2016
Abstract
PURPOSE: Establishing and obtaining consistent quantitative indices of retinal thickness from a variety of clinically used Spectral-Domain Optical Coherence Tomography scanners.
DESIGN: Retinal images from five Spectral-Domain Optical Coherence Tomography scanners were used to determine total retinal thickness with scanner-specific correction factors establishing consistency of thickness measurement across devices.
PARTICIPANTS: 55 Fovea-centered Spectral-Domain Optical Coherence Tomography volumes from eleven subjects were analyzed, obtained from Cirrus HD-OCT, RS-3000, Heidelberg Spectralis, RTVue and Topcon2000, seven subjects with retinal diseases and four normal controls.
METHOD: The Iowa Reference Algorithm measured total retinal thickness. Nonlinear model of total retinal thickness measurement comparisons was derived and used for device-specific comparisons. Bland-Altman plots and pairwise predictive equations yielded pairwise scanner-specific differences. Mendel test determined whether measurement biases were constant for each scanner pair.
RESULTS: Mendel test revealed that all pairwise scanner differences of total retinal thickness were constant across the cohort (p=0.992). Individual measurements can thus be bias-corrected and the Iowa Reference Algorithm serve as a scanner-agnostic independent standard of total retinal thickness across the five tested SD-OCT scanners.
CONCLUSIONS: Combination of the Iowa Reference Algorithm with scanner-specific bias correction yields cross-scanner consistency of total retinal thickness measurements, facilitating scanning-device independent quantitative assessment of total retinal thickness, longitudinal follow-up quantification without requiring patients to be imaged on the same scanner model, and allowing for multi-center studies with heterogeneous device utilization when using the Iowa Reference Algorithm.
Details
- Title: Subtitle
- Reproducibility of Retinal Thickness Measurements across Spectral-Domain Optical Coherence Tomography Devices using Iowa Reference Algorithm
- Creators
- Adnan RashidSebastian M WaldsteinBianca S GerendasHrvoje BogunovicAndreas WahleKyungmoo LeeKai WangChristian SimaderMichael D AbramoffUrsula Schmidt-ErfurthMilan Sonka
- Resource Type
- Preprint
- Publication Details
- ArXiv.org
- ISSN
- 2331-8422
- Number of pages
- 14 pages
- Language
- English
- Date posted
- 12/19/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Biostatistics; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984186928502771
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