Salience network and cognitive impairment in Parkinson's disease

Brooke E Yeager; Hunter P Twedt; Joel Bruss; Jordan Schultz; Nandakumar S Narayanan

doi:10.1101/2023.10.13.23296825

Back

Salience network and cognitive impairment in Parkinson's disease

Preprint

Open access

Salience network and cognitive impairment in Parkinson's disease

Brooke E Yeager, Hunter P Twedt, Joel Bruss, Jordan Schultz and Nandakumar S Narayanan

medRxiv : the preprint server for health sciences

Cold Spring Harbor laboratory

10/14/2023

DOI: 10.1101/2023.10.13.23296825

PMCID: PMC10593050

PMID: 37873396

Files and links (1)

url

https://doi.org/10.1101/2023.10.13.23296825View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Parkinson's disease (PD) is a neurodegenerative disease with cognitive as well as motor impairments. While much is known about the brain networks leading to motor impairments in PD, less is known about the brain networks contributing to cognitive impairments. Here, we leveraged resting-state functional magnetic resonance imaging (rs-fMRI) data from the Parkinson's Progression Marker Initiative (PPMI) to examine network dysfunction in PD patients with cognitive impairment. We tested the hypothesis that cognitive impairments in PD involve altered connectivity of the salience network (SN), a key cortical network that detects and integrates responses to salient stimuli. We used the Montreal Cognitive Assessment (MoCA) as a continuous index of coarse cognitive function in PD. We report two major results. First, in 82 PD patients we found significant relationships between lower intra-network connectivity of the frontoparietal network (FPN; comprising the dorsolateral prefrontal and posterior parietal cortices bilaterally) with lower MoCA scores. Second, we found significant relationships between lower inter-network connectivity between the SN and the basal ganglia network (BGN) and the default mode network (DMN) with lower MoCA scores. These data support our hypothesis about the SN and provide new insights into the brain networks contributing to cognitive impairments in PD.

basal ganglia network

functional connectivity

default mode network

salience network

Parkinson’s disease

cognitive impairments

Details

Title: Subtitle: Salience network and cognitive impairment in Parkinson's disease
Creators: Brooke E Yeager - University of Iowa
Hunter P Twedt - University of Iowa
Joel Bruss - University of Iowa
Jordan Schultz - University of Iowa
Nandakumar S Narayanan - University of Iowa
Resource Type: Preprint
Publication Details: medRxiv : the preprint server for health sciences
DOI: 10.1101/2023.10.13.23296825
PMID: 37873396
PMCID: PMC10593050
Publisher: Cold Spring Harbor laboratory; United States
Grant note: T32 NS007421 / NINDS NIH HHS K23 NS117736 / NINDS NIH HHS R01 NS100849 / NINDS NIH HHS
Language: English
Date posted: 10/14/2023
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Pharmacy Practice and Science
Record Identifier: 9984635125402771

Metrics

5 Record Views