Sex similarities and dopaminergic differences in interval timing

Hannah R. Stutt; Matthew A. Weber; Rachael C. Cole; Alexandra S. Bova; Xin Ding; Madison S. McMurrin; Nandakumar S. Narayanan

doi:10.1101/2023.05.05.539584

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Sex similarities and dopaminergic differences in interval timing

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Sex similarities and dopaminergic differences in interval timing

Hannah R. Stutt, Matthew A. Weber, Rachael C. Cole, Alexandra S. Bova, Xin Ding, Madison S. McMurrin and Nandakumar S. Narayanan

bioRxiv

Cold Spring Harbor Laboratory

05/05/2023

DOI: 10.1101/2023.05.05.539584

PMCID: PMC10187305

PMID: 37205472

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https://doi.org/10.1037/bne0000577View

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https://doi.org/10.1101/2023.05.05.539584View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles.This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Rodent behavioral studies have largely focused on male animals, which has limited the generalizability and conclusions of neuroscience research. Working with humans and rodents, we studied sex effects during interval timing that requires participants to estimate an interval of several seconds by making motor responses. Interval timing requires attention to the passage of time and working memory for temporal rules. We found no differences between human females and males in interval timing response times (timing accuracy) or the coefficient of variance of response times (timing precision). Consistent with prior work, we also found no differences between female and male rodents in timing accuracy or precision. In female rodents, there was no difference in interval timing between estrus and diestrus cycle stages. Because dopamine powerfully affects interval timing, we also examined sex differences with drugs targeting dopaminergic receptors. In both female and male rodents, interval timing was delayed after administration of sulpiride (D2-receptor antagonist), quinpirole (D2-receptor agonist), and SCH-23390 (D1-receptor antagonist). By contrast, after administration of SKF-81297 (D1-receptor agonist), interval timing shifted earlier only in male rodents. These data illuminate sex similarities and differences in interval timing. Our results have relevance for rodent models of both cognitive function and brain disease by increasing represenation in behavioral neuroscience.

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Title: Subtitle: Sex similarities and dopaminergic differences in interval timing
Creators: Hannah R. Stutt - University of Iowa
Matthew A. Weber - University of Iowa
Rachael C. Cole
Alexandra S. Bova - University of Iowa
Xin Ding - University of Iowa
Madison S. McMurrin - University of Iowa
Nandakumar S. Narayanan - University of Iowa
Resource Type: Preprint
Publication Details: bioRxiv
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2023.05.05.539584
PMID: 37205472
PMCID: PMC10187305
Language: English
Date posted: 05/05/2023
Academic Unit: Iowa Neuroscience Institute; Neurology; Psychiatry
Record Identifier: 9984413074202771

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Sex similarities and dopaminergic differences in interval timing

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