Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol

Lyndsay Harshman; Elliot Stalter; Silvia Verhofste; John Dagle; Emily Steinbach; Patrick Ten Eyck; Linder Wendt; Jeffrey Segar

doi:10.21203/rs.3.rs-3911085/v1

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Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol

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Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol

Lyndsay Harshman, Elliot Stalter, Silvia Verhofste, John Dagle, Emily Steinbach, Patrick Ten Eyck, Linder Wendt and Jeffrey Segar

Research square

02/05/2024

DOI: 10.21203/rs.3.rs-3911085/v1

PMCID: PMC10889073

PMID: 38405851

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https://doi.org/10.21203/rs.3.rs-3911085/v1View

Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Objective Evaluate the impact of a sodium (Na) supplementation protocol based upon urine Na concentration on growth parameters and morbidities. Study Design Retrospective cohort study of infants 26 0/7 -33 6/7 weeks gestational age (GA) cared for before (2012-15, n = 225) and after (2016-20, n = 157) implementation of the protocol. Within- and between-group changes over time were assessed using repeated measures generalized linear models. Results For infants 26 0/7 -29 6/7 weeks GA, utilization of the protocol was associated with increased mean body weight z-score at 8-weeks postnatal age, increased mean head circumference z-score at 16-weeks postnatal age, and decreased time on mechanical ventilation (all p < 0.02). No impact on growth was identified for infants 30–33 6/7 weeks GA. Incidences of hypertension, hypernatremia, bronchopulmonary dysplasia, and culture positive sepsis were unaffected by the protocol. Conclusion Protocolized Na supplementation results in improved growth and reduced time on invasive mechanical ventilation in extremely preterm infants without increasing incidence of morbidities.

Details

Title: Subtitle: Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol
Creators: Lyndsay Harshman - University of Iowa
Elliot Stalter
Silvia Verhofste
John Dagle - University of Iowa
Emily Steinbach
Patrick Ten Eyck
Linder Wendt
Jeffrey Segar
Resource Type: Preprint
Publication Details: Research square
DOI: 10.21203/rs.3.rs-3911085/v1
PMID: 38405851
PMCID: PMC10889073
Language: English
Date posted: 02/05/2024
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Biology; Radiation Oncology; Biochemistry and Molecular Biology; Neonatology; Design Biostat and Ethics
Record Identifier: 9984562590402771

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