Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status

Victoria Muller Ewald; Nicholas T. Trapp; McCall E. Sarrett; Benjamin D. Pace; Linder Wendt; Jenny Richards; Ilisa Gala; Jacob Miller; Jan Wessel; Vincent Magnotta; John Wemmie; Aaron Boes; Krystal Parker

doi:10.21203/rs.3.rs-3006203/v1

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Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status

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Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status

Victoria Muller Ewald, Nicholas T. Trapp, McCall E. Sarrett, Benjamin D. Pace, Linder Wendt, Jenny Richards, Ilisa Gala, Jacob Miller, Jan Wessel, Vincent Magnotta, …

Research Square

American Journal Experts

06/02/2023

DOI: 10.21203/rs.3.rs-3006203/v1

PMCID: PMC10312933

PMID: 37398216

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Preprint (Author's original)This preprint has not been evaluated by subject experts through peer review. Preprints may undergo extensive changes and/or become peer-reviewed journal articles. Open Access

Abstract

Background : Widely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show impairments in interval timing tasks, including supra-second, sub-second, and implicit motor timing compared to the neuronormative population. However, how time perception differs within individuals with BD based on BD sub-type (BDI vs II), mood, or antipsychotic medication-use has not been thoroughly investigated. The present work administered a supra-second interval timing task concurrent with electroencephalography (EEG) to patients with BD and a neuronormative comparison group. As this task is known to elicit frontal theta oscillations, signal from the frontal (Fz) lead was analyzed at rest and during the task. Results : Results suggest that individuals with BD show impairments in supra-second interval timing and reduced frontal theta power compared during the task to neuronormative controls. However, within BD sub-groups, neither time perception nor frontal theta differed in accordance with BD sub-type, mood, or antipsychotic medication use. Conclusions : his work suggests that BD sub-type, mood status or antipsychotic medication use does not alter timing profile or frontal theta activity. Together with previous work, these findings point to timing impairments in BD patients across a wide range of modalities and durations indicating that an altered ability to assess the passage of time may be a fundamental cognitive abnormality in BD.

Details

Title: Subtitle: Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status
Creators: Victoria Muller Ewald - University of Iowa
Nicholas T. Trapp - University of Iowa
McCall E. Sarrett - Villanova University
Benjamin D. Pace - University of Iowa
Linder Wendt - University of Iowa
Jenny Richards - University of Iowa
Ilisa Gala - University of Iowa
Jacob Miller - St. Luke’s Hospital
Jan Wessel - University of Iowa
Vincent Magnotta - University of Iowa
John Wemmie - University of Iowa
Aaron Boes - University of Iowa
Krystal Parker - University of Iowa
Resource Type: Preprint
Publication Details: Research Square
DOI: 10.21203/rs.3.rs-3006203/v1
PMID: 37398216
PMCID: PMC10312933
Publisher: American Journal Experts
Language: English
Date posted: 06/02/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
Record Identifier: 9984442225802771

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